Evaluation of ARTN and PSPN Gene Polymorphisms in Breast Cancer Risk: Insights from a Case-Control Study in Turkish Population

Authors : Tuba Taşkan Susam, Osman Kurukahvecioğlu, Niyazi Karaman, Aymelek Gönenç

Pages : 1-6

Doi:10.20515/otd.1684002

View : 169 | Download : 244

Publication Date : 2025-12-15

Article Type : Research Paper

Abstract :RET is a member of the receptor tyrosine kinase family, which is essential for the normal development and maturation of various tissues. RET signaling promotes changes in the tumor microenvironment that alter the surrounding stroma and cellular composition. Gene polymorphisms of RET and its ligands artemin (ARTN) and persephin (PSPN) are a research focus in cancer pathogenesis, risk, invasion, and metastasis. Although RET polymorphisms have been investigated in various cancers in many ethnicities and populations, there are limited studies in the literature on the effect of ARTN and PSPN polymorphisms on breast cancer risk. The study included 102 breast cancer patients and 102 healthy controls. rs3762422 and rs2304198 polymorphisms were detected by polymerase chain reaction and sequencing methods and genotype distributions were determined. The study groups showed a similar profile in terms of genotype distributions in both variants and no statistically significant difference was found (p>0.05, p>0.05, respectively). Our findings suggest that ARTN rs3762422 and PSPN rs2304198 polymorphisms are not associated with breast cancer risk in our cohort. In this study, we aimed to investigate and evaluate the possible risk between ARTN gene rs3762422 and PSPN gene rs2304198 variants and breast cancer. To our knowledge, this is the first study investigating these variants in breast cancer, and it may contribute to future research.
Keywords : Meme Kanseri, RET, Artemin, Persephin, Polimorfizm

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