Factors associated with frequency and severity of COVID-19 in patients with axial spondyloarthritis

Authors : Mete PEKDİKER, Mete KARA, Emrah KOÇ, Gezmiş KİMYON

Pages : 404-411

Doi:10.31362/patd.1223660

View : 87 | Download : 105

Publication Date : 2023-07-01

Article Type : Research Paper

Abstract :Purpose: The severe course of COVID-19 in individuals with chronic diseases has led to concerns in managing rheumatic diseases during the pandemic; therefore, we aimed to define the factors associated with the frequency and severity of COVID-19 in patients with axial spondyloarthritis insert ignore into journalissuearticles values(axSpa); in this study. Materials and methods: Patients with axSpa who were followed up in three tertiary hospitals and used their treatment regularly for at least six months were included. We assessed the relationship between axSpa-associated variables such as disease duration time, radiological severity, treatment and COVID-19 outcomes. Results: A total of 833 patients with a mean disease duration of 109 months were analyzed; 64.5% of them had ankylosing spondylitis, 35.5% had non-radiographic axSpa, and 59.4% of patients were treated with a biologic agent. The frequency of COVID-19 was 23% insert ignore into journalissuearticles values(n:192);; only five patients insert ignore into journalissuearticles values(0.5%); had a history of intensive care unit. Advanced age, hypertension insert ignore into journalissuearticles values(HT);, and diabetes mellitus insert ignore into journalissuearticles values(DM); were found to be significantly more common in those with involvement in high-resolution computed tomography insert ignore into journalissuearticles values(HRCT); insert ignore into journalissuearticles values(p:0.02, p:0.01, and p<0.001);. In hospitalized individuals, female gender, HT, DM, and disease lasting longer than 10 years were significantly higher insert ignore into journalissuearticles values(p:0.03, p:0.011, p<0.001, and p:0.014);. Only DM was found as an independent risk factor for both pulmonary involvement in HRCT insert ignore into journalissuearticles values(p:0.029); and hospitalization insert ignore into journalissuearticles values(p:0.001);. Conclusion: We conducted our study with a homogenous study population and our results suggested that biological agents did not affect poor COVID-19 outcomes; only DM was associated with a more severe COVID-19 course in patients with axSpa.
Keywords : COVID 19, aksiyel spondiloartrit, ankilozan spondilit, radyografik olmayan aksiyel spondiloartrit, şeker hastalığı