Frequency of asymptomatic hyperuricemia in advanced-stage symptomatic knee osteoarthritis and its relationship with inflammatory parameters

Authors : Reyhan Köse Çobanoğlu, Bilal Bedirhan Akbaş, Vahit Yıldız, Ferit Tufan Özgezmez

Pages : 412-418

Doi:10.31362/patd.1407943

View : 102 | Download : 135

Publication Date : 2024-07-05

Article Type : Research Paper

Abstract :Purpose: Hyperuricemia (HU) is thought to be a risk factor in the development and progression of knee osteoarthritis (OA). We sought the frequency of asymptomatic HU in advanced knee OA patients and whether it was related to systemic inflammation. Materials and methods: This is a single-center, retrospective study including patients with symptomatic stage 3/4 knee OA classified based on Kellgren-Lawrence (K-L) system. Demographic data and serum uric acid (UA), hemogram parameters, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), body mass index (BMI) were recorded. Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and systemic immune-inflammation index (SII)=[(neutrophil count × platelet count)/lymphocyte count] were calculated. Patients with/without hyperuricemia were defined as Group 1 and Group 2, respectively. Demographic and laboratory data were compared between the groups. Results: Hyperuricemia was present in 51 of 240 patients (21%). There was no significant difference between the groups based on age (Group1: 70.54±7.02, Group2: 68.63±6.29, p=0.07) and BMI (Group 1: 34 kg/m2 (27.7-41), Group2: 32 kg/m2 (25-51.5), p=0.107). NLR, PLR, and SII were similar between two groups (p=0.404, p=0.604, p=0.537). While there was no difference in ESR values between the two groups (p=0.051), CRP levels were found to be significantly higher in Group 1 (p=0.007). A positive correlation was detected between serum UA level and CRP (rho=0.243**, p<0.001), SII (rho=0.173*, p=0.017), NLR (rho=0.154*, p=0.035) and PLR (rho=0.166*, p=0.023) in Group 2. No correlation was detected between serum UA level and ESR, CRP, SII, NLR, PLR and BMI in Group 1. Conclusion: Asymptomatic HU was found 1 in 5 of advanced-stage knee OA patients and may contribute to inflammation in knee OA. Serum UA level may need to be reduced to normal level in these patients.
Keywords : Asemptomatik hiperürisemi, hiperürisemi, diz osteoartriti, sistemik inflamasyon