HSPB7 and tetranectin levels are associated with severity of COVID-19

Authors : Özgen Kılıç Erkek, Gülşah Gündoğdu, Davut Akın, Z. Melek Küçükatay
Pages : 696-705
Doi:10.31362/patd.1685453
View : 53 | Download : 54
Publication Date : 2025-07-02
Article Type : Research Paper
Abstract :Purpose: COVID-19 may have acute and chronic adverse effects on the cardiovascular system. Heat shock protein beta-7 (HSPB7) is a cardiovascular heat-shock protein, and tetranectin is a type-C calcium (Ca)-binding lectin. The present study was conducted to investigate the relationship between HSPB7, tetranectin, disease severity and myocardial injury in COVID-19. Materials and methods: This study included 26 COVID-19 patients and 26 age and sex-matched healthy controls. Demographic characteristics, routine hemograms, and biochemical parameters were recorded. COVID-19 patients were classified as having mild to moderate and severe COVID-19 using clinical and laboratory data. HSPB7 and tetranectin levels were measured using commercial ELISA kits. Results: C-reactive protein, fasting glucose, ferritin, neutrophil-to-lymphocyte, monocyte-to-lymphocyte, and platelet-to-lymphocyte ratios were significantly elevated, whereas calcium, and albumin were decreased in COVID-19 patients (p<0.05). Respiratory rate, D-dimer, and ferritin were higher while SO2 and lymphocyte counts were lower in severe COVID-19 patients (p<0.05). Serum HSPB7 levels were higher in COVID-19 patients vs healthy controls (p<0.01), whereas tetranectin concentration was lower (p<0.001). When the cases were evaluated according to the severity of the disease it was observed that, HSPB7 level was increased in patients with severe COVID-19 and tetranectin was decreased parallel to the severity of the disease (p<0.001 and p<0.001, respectively). HSPB7 concentration was positively correlated with ferritin (p=0.002). Tetranectin was negatively correlated with HSPB7, ferritin and troponin (p=0.041, p<0.01, and p=0.005, respectively). Conclusion: The consequence of the present study indicates tetranectin as a potential biomarker for an accurate and more comprehensive understanding severity of cardiac damage in COVID-19 patients.
Keywords : COVID-19, HSPB7, tetranektin, kardiyak hasar

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