ANTIMICROBIAL ACTIVITY AND THE PHENOLIC PROFILE OF FIVE SCROPHULARIA L. SPECIE

Authors : Gülin RENDA, Büşra KORKMAZ, Sercan YILDIRIM, Ahu REİS, Nurdan Yazici BEKTAŞ, Serhat SEVGİ, Sevda TÜRKİŞ, M Erkan UZUNHİSARCIKLI, Ahmet YAŞAR, İlknur TOSUN

Pages : 10-15

View : 33 | Download : 16

Publication Date : 2018-03-01

Article Type : Research Paper

Abstract :Scrophularia L. genus insert ignore into journalissuearticles values(Scrophulariaceae); has 310 taxa worldwide. Some Scrophularia species are used in folk medicine for the treatment of different skin inflammatory diseases and as antibacterial. The aim of the study was to investigate the antimicrobial activity and determine the phenolic profile of S. kotscyhana Bentham, S. cinarescens Boiss., S. catariifolia Boiss. & Heldr., S. chrysantha Jaub&Spach and S. scopolii var. adenocalyx Hoppe. ex Pers. Phenolic components were analyzed by an HPLC-DAD method. Disk diffusion method and microtiter-plate assay were used to determine the antimicrobial activities of the aerial parts methanolic extracts of the species. Our results revealed that all of the tested species contain caffeic acid and ferulic acid in varied concentrations and none of them have chlorogenic acid. All of the plant species exhibited moderate activity against Candida albicans insert ignore into journalissuearticles values(MIC values; 0.3125 mg/mL);. Besides, S. cinarescens exhibited moderate activity against Enterococcus faecalis insert ignore into journalissuearticles values(MIC value; 0.3125 mg/ mL); and S. chrysantha exhibited moderate activity against Pseudomonas aeruginosa insert ignore into journalissuearticles values(MIC value; 0.3125 mg/mL);. The results of this study showed that further studies were needed to identify the secondary metabolites of the species and evaluate their antimicrobial activities.
Keywords : Antimicrobial activity, HPLC DAD, microtiter plate assay, medicinal plants, Scrophularia species

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