Relation of Red Cell Distribution Widht with Ascending Aortic Diameter in Bicuspid Aortic Valve Patients

Authors : Abdullah Nabi ASLAN, Serdal BAŞTUĞ, Muhammed Cihad ÇELİK, Hacı Ahmet KASAPKARA, Mehmet Murat YİĞİTBAŞI, Yunus Emre ÖZBEBEK, Engin BOZKURT

Pages : 327-335

Doi:10.31832/smj.389878

View : 26 | Download : 6

Publication Date : 2018-06-29

Article Type : Research Paper

Abstract :Objective: Red cell distribution widht insert ignore into journalissuearticles values( RDW); and neutrophil to lymphocyte ratio insert ignore into journalissuearticles values(NLR);   plays a significant role in assessing the severity and progression of some cardiac conditions. Bicuspid aortic valve  insert ignore into journalissuearticles values(BAV);-associated aortopathy is common and its progression for individual patients is difficult to predict. In this study, we aimed to investigate the association between serum levels of RDW, NLR and ascending aortic diameter insert ignore into journalissuearticles values(AAd);   in BAV patients. Methods: A total of 182 consecutive patients with a BAV were recruited into this study. Complete blood counts were analyzed for RDW level and NLR. Patients   were divided into two groups based on their AAd and patients with AAd of 3.9 and above were included in group 1, while those below 3.9 in group 2. Results: NLR was significantly higher in group 1 patients than those in group 2. RDW levels were similar. In univariate correlation analysis, a positive correlation was found between AAd and RDW and NLR in group 1 patients. In multivariate logistic regression analysis, RDW insert ignore into journalissuearticles values(odds ratio insert ignore into journalissuearticles values(OR);: 1.78, 95% confidence interval insert ignore into journalissuearticles values(CI);: 1.36–2.44, P = 0.01); remained as independent correlates of AAd in the patient population. Receiver operating characteristic insert ignore into journalissuearticles values(ROC); curve analysis reveled that a RDW measurement >13.0% predicted ascending aort dilatation insert ignore into journalissuearticles values(AAD); with a sensitivity of 58% and a specificity of 79%. Conclusion: RDW and NLR are positively correlated with AAd in BAV patients with AAD. These markers may point out the role of inflammation both in the pathogenesis and progression of AAD   in these patients.
Keywords : Bicuspid aortic valve, ascending aortic diameter, red cell distribution widht