The relationship between neutrophil-lymphocyte ratio and antibiotic therapy in patients with fever of unknown origin

Authors : Cengiz KARACAER, Oğuz KARABAY, Ali TAMER

Pages : 25-31

Doi:10.31832/smj.813151

View : 26 | Download : 11

Publication Date : 2021-03-22

Article Type : Research Paper

Abstract :Objective: Empirical antibiotic therapy is usually applied by physicians to patients with fever when the origin of the infection cannot yet be determined.The aim of this study is to determine the cost-effectiveinflammatoryparametersin empirical antibiotic therapy in patients with fever of unknown origininsert ignore into journalissuearticles values(FUO);. Materials and Methods:A total of 577 patients, whose blood cultures were taken and followed up by the NBA, were divided into two groups as fever group due to infectioninsert ignore into journalissuearticles values(IRFG); and fever group not related to infectioninsert ignore into journalissuearticles values(NIRFG);, and their five-year data were analyzed retrospectively from the patient information registry system.From the complete blood count test results, the neutrophil count was proportioned to the lymphocyte count parameter, and the neutrophil lymphocyte ratio and thrombocyte lymphocyte ratio values were calculated. Results: Total of 577 patients were divided into two groups as infection related fever group insert ignore into journalissuearticles values(IRFG); and non-infection related fever group insert ignore into journalissuearticles values(NIRFG);, and were included in the study. The durations of first antibiotic usages were 4.54 ± 3.08insert ignore into journalissuearticles values(1–14); days and 5.35 ± 3.8insert ignore into journalissuearticles values(1–21); days in IRFG and NIRFG, respectively. Neutrophil-to-lymphocyte ratio insert ignore into journalissuearticles values(NLR); was 8.00 insert ignore into journalissuearticles values(3.00-15.00); in the IRFG, whereas it was 5.00 insert ignore into journalissuearticles values(3.00-9); in the NIRFG insert ignore into journalissuearticles values(p = 0.001);. Platelet-to-lymphocyte ratio insert ignore into journalissuearticles values(PLR); was 21.00 insert ignore into journalissuearticles values(9.00-41.00); in the IRFG, whereas it was 16.00 insert ignore into journalissuearticles values(7.25-27.75); in the NIRFG and was not significant insert ignore into journalissuearticles values(p = 0.165);. Conclusion:Since neutrophil-lymphocyte ratio can be checked from routine blood tests and is not an expensive method, it can be used as an advantageous diagnostic method in patients with fever of unknown origininsert ignore into journalissuearticles values(FUO);.
Keywords : Empirical antibiotic therapy, Fever of unknown origin, Neutrophil to lymphocyte ratio, Platelet to lymphocyte ratio