Clinical features and survival outcomes of unclassified high-grade neuroendocrine carcinoma of the lung

Authors : Yasemin SÖYLER, Pınar AKIN KABALAK, Suna KAVURGACI, Funda DEMİRAĞ, Ülkü YILMAZ

Pages : 295-304

Doi:10.31832/smj.1277259

View : 29 | Download : 31

Publication Date : 2023-06-30

Article Type : Research Paper

Abstract :Background: Differentiating high-grade neuroendocrine carcinomas insert ignore into journalissuearticles values(HGNEC); is difficult. We aimed to assess the clinical features and survival outcomes of unclassified HGNEC insert ignore into journalissuearticles values(uHGNEC); and to compare it with small-cell lung cancer insert ignore into journalissuearticles values(SCLC);. Material and Methods: This was a retrospective and observational study of HGNEC patients. Kaplan-Meier method was used to estimate progression-free survival insert ignore into journalissuearticles values(PFS); and overall survival insert ignore into journalissuearticles values(OS);. Cox-regression analyses were used to determine the risk factors independently associated with PFS and OS. Results: One hundred twenty-one patients [uHGNEC insert ignore into journalissuearticles values(n = 35);, SCLC insert ignore into journalissuearticles values(n = 86);] were analysed. The primary tumour was mostly right-sided, located in the centre of the lungs. The IASLC stage at diagnosis was locally advanced in 43 insert ignore into journalissuearticles values(35.5%); patients and advanced in 78 insert ignore into journalissuearticles values(64.5%); patients. uHGNEC and SCLC groups shared similar clinical features. The study population\`s median PFS and OS were 8.8 insert ignore into journalissuearticles values(95%Cl 7.29 – 10.30); and 10.9 insert ignore into journalissuearticles values(95%Cl 9.9 – 11.8); months, respectively. uHGNEC- and SCLC groups had a similar PFS insert ignore into journalissuearticles values(9.4 vs 8.6 months, p = 0.99); and OS insert ignore into journalissuearticles values(12 vs 10.7 months, p = 0.51);. The six-month, one- and two-year PFS and OS of two groups were also similar. Among all patients, a right-sided tumour insert ignore into journalissuearticles values(HR: 1.558, 95%Cl 1.044 – 2.325, p = 0.03); and advanced-stage disease insert ignore into journalissuearticles values(HR: 1.928, 95%Cl 1.292 – 2.877, p = 0.001); were prognostic factors for poor OS. Cox-regression analysis indicated that histopathology did not have an impact on PFS and OS. Conclusion: HGNEC patients who cannot be classified pathologically behave like SCLC.
Keywords : yüksek dereceli nöroendokrin karsinoma, küçük hücreli akciğer kanseri, nöroendokrin tümörler