Synthesis and Characterization of Thiazole Compounds in the Presence of Various Reagents, Catalysts and Solvents

Authors : Nurcan BERBER

Pages : 757-767

Doi:10.16984/saufenbilder.950016

View : 19 | Download : 11

Publication Date : 2022-08-31

Article Type : Research Paper

Abstract :The reaction medium plays a key role in organic synthesis and pharmaceutical research. There are many opinions on choosing the best condition, including cost and environmental implications, but the main requirement is that they have the necessary interaction with solvents to cause dissolution, precipitation, stabilization, or instability. For this purpose, in this article synthesis of the thiazole ring was made under various reaction conditions. So new compounds 2-insert ignore into journalissuearticles values(isoquinolin-5-ylimino);-3-phenylthiazolidin-4-one insert ignore into journalissuearticles values(1);, insert ignore into journalissuearticles values(4-amino-3-phenylthiazol-2insert ignore into journalissuearticles values(3H);-ylidene); isoquinolin-5-amine insert ignore into journalissuearticles values(2);, insert ignore into journalissuearticles values(4-amino-3-phenylthiazol-2insert ignore into journalissuearticles values(3H);-ylidene); isoquinolin-5-amine insert ignore into journalissuearticles values(3); were synthesized from the reaction between thiourea derivative and monochloroacetic acid, diethyloxalate and chloro acetonitrile. For this synthesizes were created in various reaction conditions, using different bases insert ignore into journalissuearticles values(sodium acetate/sodyum etoksit/ triethylamine or pyridine); and solvents insert ignore into journalissuearticles values(1,4-dioxane, toluene, acetic acid, ethanol, tetrahydrofuran, dimethyl formamide);. At the end of these reactions, the best efficiency was obtained with the one-pot reaction using THF/DMF, Et3N. The structures of all novel compounds reported herein were established using FT-IR, 1H NMR, and 13C NMR spectra as well as elemental analysis technique.
Keywords : 5 aminoisoquinoline, thioureas, thiazole rings, one pot reaction