Synthesis, DPPH and ABTS Activity of Novel Furfuryl-Chalcone Derivatives

Authors : Fatih SÖNMEZ, Enes AKGÜN, Zuhal ŞAHİN

Pages : 1224-1232

View : 22 | Download : 7

Publication Date : 2022-12-31

Article Type : Research Paper

Abstract :In this study, novel furfuryl-chalcone derivatives substituted sulfonyl chloride or sulphonamide were synthesized. Their antioxidant properties were investigated via DPPH and ABTS assays. All furfuryl-chalcones had high antioxidant properties. Among them, insert ignore into journalissuearticles values(E);-5-insert ignore into journalissuearticles values(3-insert ignore into journalissuearticles values(4-insert ignore into journalissuearticles values(chlorosulfonyl);-3-hydroxyphenyl);-3-oxoprop-1-en-1-yl);furan-2-sulfonyl chloride insert ignore into journalissuearticles values(4e); and insert ignore into journalissuearticles values(E);-5-insert ignore into journalissuearticles values(3-insert ignore into journalissuearticles values(3-insert ignore into journalissuearticles values(chlorosulfonyl);-4-hydroxyphenyl);-3-oxoprop-1-en-1-yl);furan-2-sulfonyl chloride insert ignore into journalissuearticles values(4d); exhibited the highest DPPH activity with the IC50 values of 4.23 μM and 6.68 μM, respectively, which are almost 2- and 1.5-fold more than quercetin activity insert ignore into journalissuearticles values(IC50 = 8.69 μM);, well-known as antioxidant agent and used as a standard. Also, 4e and 4d had the highest ABTS activity with the IC50 value of 5.55 μM and 7.84 μM, respectively, which are almost 2.8- and 2-fold higher than that of quercetin insert ignore into journalissuearticles values(IC50 = 15.49 μM);. The structure-activity relationship results revealed that most of synthesized sulfonyl chloride derivatives insert ignore into journalissuearticles values(4a-e); have higher antioxidant activity than the sulphonamide derivatives insert ignore into journalissuearticles values(5a-c); and also 4d and 4e, including hydroxyl group, exhibited the strongest antioxidant activity as expected.
Keywords : Antioxidant activity, chalcone, furan