Isparta bölgesinde mide kanserli hastalarda helikobakter pilori sıklığı

Authors : Nermin Karahan, Sema Bircan, Nilgün Kapucuoğlu, Şirin Başpınar, Özden Çandır, Ersin USKUN

Pages : 30-33

Doi:10.17343/sdutfd.39946

View : 20 | Download : 8

Publication Date : 2009-04-08

Article Type : Research Paper

Abstract :SüleymanDemirel Üniversitesi TIP FAKÜLTESİ DERGİSİ: 2005 Haziran; 12insert ignore into journalissuearticles values(2); Isparta bölgesinde mide kanserli hastalarda helikobakter pilori sıklığı Nermin Karahan, Sema Bircan,Nilgün Kapucuoğlu, Şirin Başpınar, Özden Çandır, Ersin Uskun Özet Helikobakter pilori insert ignore into journalissuearticles values(HP); ilk kez 1983 yılında Warren ve Marshall tarafından kültürü yapılan gram negatif bakteridir. Helikobakter pilori`nin mide karsinom gelişmesinde prekürsör lezyon olan kronik atrofik gastrit ve intestinal metaplaziye neden olması, gastrik karsinomların patogenezinde olası rolünü gündeme getirmiştir. Çalışmamızda mide karsinomlarında histolojik olarak gastrit, intestinal metaplazi ile helikobakter pilori arasındaki ilişkiyi araştırmayı amaçladık. Bu çalışmada son 5 yılda mide kanseri nedeniyle total yada subtotal gastrektomi yapılan 34 olgu incelenerek histolojik tiplerine ayrıldı. Helikobakter pilori`yi araştırmak için Toluidin mavisi boyama yöntemi kullanıldı. 34 mide karsinomlu olgunun 30`u intestinal tip insert ignore into journalissuearticles values(%88.2); 4`ü diffüz tip insert ignore into journalissuearticles values(%11.8); idi. Olguların tümünde kronik gastirit vardı. Aktif kronik gastrit 22 olguda insert ignore into journalissuearticles values(%64.7); inaktif gastrit 12`sinde insert ignore into journalissuearticles values(%35.3); vardı. İntestinal tip mide adenokarsinomlarının 23`ünde insert ignore into journalissuearticles values(%76.6);, 4 diffüz tip karsinomun 4`ünde insert ignore into journalissuearticles values(%100); intestinal metaplazi izlendi. Helikobakter pilori 34 olgunun 24`ünde insert ignore into journalissuearticles values(%70.6); pozitif bulundu. Helikobakter pilori enfeksiyonu diffüz tipe göre intestinal tipde daha sıktı insert ignore into journalissuearticles values(p>0.05);. Aktif kronik gastritlerin 22`sinde insert ignore into journalissuearticles values(%72.7); inaktif kronik gastritlerin 5`inde insert ignore into journalissuearticles values(%35.7); Helikobakter pilori pozitif bulundu. Helikobakter pilori varlığı aktif gastritlerde inaktif gastritlere göre daha sık gibi görülmesine karşın istatistiksel olarak anlamlı değildi insert ignore into journalissuearticles values(p>0.05);. Anahtar kelimeler: Helikobakter pilori, mide adenokarsinomu Abstract Prevalence of helıcobacter pylorı ın patıents wıth gastrıc carcınoma ın Isparta regıon Helicobacter plyori is the gram negative bacteria which was cultured by Warren and Marshall first in 1983. Helicobacter pylori was frequently observed in patients with chronic gastritis. Chronic atrofic gastritis is defined as precursor lesion in the development of gastric carcinoma . Therefore, H.Pylori has an important role in pathogenesis of gastric carcinoma . Our study aimed to examine the association between helicobacter and gastritis, intestinal metaplasia in gastric carcinomas of different histological types. In this study, 34 patients who underwent total or subtotal gastrectomy due to gastric carcinoma in last five years were examined and histologically defined . Helicobacter pylori status was evaluated by toluidine blue . Intestinal type carcinoma was observed in 30 cases out of 34 insert ignore into journalissuearticles values(%88.2);, diffuse type was found in 4 cases insert ignore into journalissuearticles values(%11.8);. Chronic gastritis was diagnosed in all cases. There were active chronic gastrtis in 22 cases insert ignore into journalissuearticles values( % 64.7); and inactive gastritis in 12 cases insert ignore into journalissuearticles values( %35);. Intestinal metaplasia was observed in 23 of 30 insert ignore into journalissuearticles values( % 76.6); with intestinal type carcinomas, 4 of 4 insert ignore into journalissuearticles values(%100); with diffuse type carcinoma. The prevalance of helicobacter was positive in 24 insert ignore into journalissuearticles values( %70.6); cases out of 34. The helicobacter pylori infection was higher in intestinal type carcinoma than diffuse type insert ignore into journalissuearticles values(p>0.05);. Helicobacter pylori was positive in 22 cases insert ignore into journalissuearticles values( % 72.2); with active gastritis and in 5 cases insert ignore into journalissuearticles values( % 35.7); with inactive gastritis. Despite the frequent existence of helicobacter pylori in active gastritis when compared to inactive gastritis, it was not statically significant insert ignore into journalissuearticles values(p>0.05);. Key words: Helicobacter Pylori,gastric adenocarcinoma
Keywords : Helikobakter pilori, mide adenokarsinomu