Topographic Features of Extracorporeal Circulation Circuit Surface Observed by Atomic Force Microscopy; Coated or Non-coated?

Authors : Kadir ÇEVİKER, Şahin ŞAHİNALP, Rasih YAZKAN

Pages : 0-0

View : 18 | Download : 9

Publication Date : 2016-06-30

Article Type : Research Paper

Abstract :Abstract Objective Polymer based materials used in the manufacture of extracorporeal circulation insert ignore into journalissuearticles values(ECC); circuit that is the main part of the heart lung machine used in cardiac surgery, poses the unavoidable inflammatory and coagulation reactions because of the contact with the tissue and biological fluids particularly the blood. The reason for these reactions may include chemical properties of the material used but the surface properties of the contact surface are also important. Atomic force microscopy insert ignore into journalissuearticles values(AFM); is useful method to analyze the surface morphology of a thin line and obtain information about the thickness, roughness and height asymmetries values such as the skewness and kurtosis of the line. The aim of the study is demonstrating the ECC circuits’ topographic features that hypothesized as one of the main reason for side effect reactions as inflammation and coagulation. Methods For this purpose, non-coated insert ignore into journalissuearticles values(n=3);, heparine coated insert ignore into journalissuearticles values(n=3); and phosphorylcholin coated insert ignore into journalissuearticles values(n=3); ECC lines imaged by AFM and surface photographs, 3d topography, skewness and kurtosis of the sectional images and surface properties were evaluated at preoperative and postoperative. Results Atomic force microscopy images of the non-coated insert ignore into journalissuearticles values(n=3);, heparine coated insert ignore into journalissuearticles values(n=3); and phosphorylcholin coated insert ignore into journalissuearticles values(n=3); ECC lines revealed that none of the circuit surface morphologies are enough for a biocompatible device. Conclusion Considering the biomaterial design approaches to date, although the influence of the chemistry of the substrate is certainly of high importance, micro/nanoscale topography on biomaterial surfaces is a promising new strategy and shows potential for improving blood compatibility.
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