EVALUATION OF LIVER ELASTICITY USING pSWE AND 2D-SWE TECHNIQUES IN HEALTHY CHILDREN

Authors : Hüseyin AYDIN, Fatma İSSİ

Pages : 69-77

Doi:10.17343/sdutfd.1252498

View : 14 | Download : 7

Publication Date : 2023-03-14

Article Type : Research Paper

Abstract :Objective Shear wave elastography insert ignore into journalissuearticles values(SWE); is a new ultrasonography technique that can non-invasively evaluate liver stiffness. The efficacy of SWE in adults has been demonstrated by numerous studies, but there are few SWE studies of pediatric groups. Since the liver stiffness values insert ignore into journalissuearticles values(LSV); vary according to the device and the SWE method used, standard reference values have not been established as yet. The aim of this study was to establish the reference values of normal liver stiffness in healthy children according to the two SWE methods. Materials and Method Liver stiffness values were measured using the two different SWE methods of point SWE insert ignore into journalissuearticles values(pSWE); and 2-dimensional SWE insert ignore into journalissuearticles values(2D-SWE); in 107 healthy children aged 8-18 years with no liver disease. The pSWE insert ignore into journalissuearticles values(EPQ); and 2D-SWE insert ignore into journalissuearticles values(EQI); measurements were taken in one session on the same device insert ignore into journalissuearticles values(Philips Epiq Elite); and after at least 4 hours of fasting. The effects on liver elasticity values were investigated of gender, age, body mass index insert ignore into journalissuearticles values(BMI);, some biochemical markers insert ignore into journalissuearticles values(such as fasting blood glucose, aspartate aminotransferase insert ignore into journalissuearticles values(AST);, alanine aminotransferase insert ignore into journalissuearticles values(ALT);, albumin, platelet, INR); and liver size. Results The mean LSV was 4.04±0.84kPa insert ignore into journalissuearticles values(insert ignore into journalissuearticles values(95% confidence interval insert ignore into journalissuearticles values(CI);:3.67-4.42);); on pSWE and 4.41±0.71kPa insert ignore into journalissuearticles values(95% CI:4.09-4.72); on 2D-SWE. The upper limit LSVs were found to be 4.42kPa and 4.72kPa, respectively. The LSVs measured on 2D-SWE were found to be higher than on pSWE insert ignore into journalissuearticles values(insert ignore into journalissuearticles values(median; min-max, 4.34kPa; 2.82-6kPa and 3.86kPa; 2.55–5.78, respectively, insert ignore into journalissuearticles values(r=0.59, p<0.001););. A low-level significant positive correlation was determined between LSV and age insert ignore into journalissuearticles values(r=0.267; p=0.006);. No significant association was determined between LSV and hepatic size, gender, BMI and biochemical markers. Conclusion In healthy children aged 8-18 years, the mean liver stiffness reference values obtained on the Philips Epiq Elite ultrasound device were 4.04±0.84kPa using the pSWE method and 4.41±0.71kPa using the 2D-SWE method.These reference values will help the SWE method to be used more effectively in the evaluation of liver parenchyma in chronic liver diseases.
Keywords : Çocuk, karaciğer sertliği, ultrason, shear wave elastografi, iki boyutlu shear wave elastografi