INVESTIGATION OF PREDICTIVE FACTORS FOR CLINICAL REMISSION IN RESPONSE TO REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) TREATMENT IN DEPRESSIVE DISORDER

Authors : Özgen ÖZÇELİK, Buket CİNEMRE, Ali ERDOĞAN, Özmen METİN

Pages : 344-352

Doi:10.17343/sdutfd.1256800

View : 21 | Download : 33

Publication Date : 2023-09-23

Article Type : Research Paper

Abstract :Objective It was aimed to examine the socio-demographic and clinical data of patients treated with Repetitive Transcranial Magnetic Stimulation insert ignore into journalissuearticles values(rTMS); for depressive disorder and to evaluate the relationship of these data with remission response to rTMS treatment. Material and Method: The medical records of 120 patients were evaluated retrospectively. Hamilton Depression Scale insert ignore into journalissuearticles values(HAM-D);, Beck Anxiety Scale insert ignore into journalissuearticles values(BAI);, and Richard-Campbell Sleep Scale insert ignore into journalissuearticles values(RCSQ); scores were analyzed. Results 60% insert ignore into journalissuearticles values(72/120); of the patients were women and the mean age was 42.80±12.80 years. According to the HAM-D scores insert ignore into journalissuearticles values(7 and below);, 41.4% insert ignore into journalissuearticles values(46/111); of the patients were in remission at the end of the treatment. In addition, when the pre-treatment and post-treatment scale scores were evaluated, HAM-D scores and BAI scores decreased significantly after treatment insert ignore into journalissuearticles values(respectively; p<0.001, p<0.001);, while RCSQ scores increased significantly after treatment insert ignore into journalissuearticles values(p<0.001);. Binary regression analysis was performed to investigate the predictive factors for remission of depressive symptoms after rTMS treatment. A high HAM-D score at the beginning of the treatment showed a negative predictive relationship with remission insert ignore into journalissuearticles values(p<0.001);, while a decrease in HAM-D scores at the second week of treatment showed a positive predictive relationship with remission insert ignore into journalissuearticles values(p=0.009);. Conclusion We may suggest that rTMS treatment reduces depression and anxiety symptoms and improves sleep quality. In addition, it can be said that the severe depression before the rTMS treatment reduces the likelihood of going into remission, whereas the decrease in the severity of depression observed in the second week of the treatment increases this likelihood.
Keywords : Depresyon, Tekrarlayan transkraniyal manyetik stimülasyon, rTMS, Prediktif faktörler, Remisyon