PRODUCTION AND OPTIMIZATION METHOD OF SMART HYDROGELS BASED ON BIOCOMPATIBLE POLYMER FOR CONTROLLED INSULIN RELEASE

Authors : Hediye Irem OZGUNDUZ, Hava Gizem KANDILCI, Nil ACARALI, Hanifi SARAC

Pages : 115-122

View : 38 | Download : 9

Publication Date : 2016-03-01

Article Type : Research Paper

Abstract :The aim of controlled insulin delivery study experiments is to produce the smart hydrogel to use insulin release for human body. Insulin entrapped pinsert ignore into journalissuearticles values(HEMA-co-Eudragit L-100); hydrogels containing different ratios of 2-Hydroxyethyl methacrylate insert ignore into journalissuearticles values(HEMA); and Eudragit L-100 were synthesized by using ammonium persulfate insert ignore into journalissuearticles values(APS); as an initiator and ethylene glycol dimethacrylate insert ignore into journalissuearticles values(EGDMA); as a cross linker and new alternative ways were worked on to find and develop. Taguchi method was used and optimum synthesis conditions were determined. Insulin was entrapped into hydrogels as synthesis. After entrapped method, loading efficiency values were calculated. and the hydrogels produced were characterized by using Fourier Transform Infrared Spectroscopy insert ignore into journalissuearticles values(FT-IR); and Scanning electron microscope insert ignore into journalissuearticles values(SEM); analysis.
Keywords : Hydrogel, insulin, Taguchi, Eudragit

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