DETERMINATION OF THE GENETIC PROFILE OF MCT1 (SLC16A1) GENE A/T POLYMORPHISM AND GDF5 GENE T/C POLYMORPHISM RELATED TO CONNECTIVE TISSUE AND MUSCLE INJURY RISK IN YOUNG ATHLETES

Authors : Merve Bektaş, Recep Sürhat Müniroğlu

Pages : 16-24

Doi:10.33689/spormetre.1487161

View : 130 | Download : 101

Publication Date : 2024-07-30

Article Type : Research Paper

Abstract :In this study, MCT1 (SLC16A1) gene A/T polymorphism related to muscle injury and GDF5 T/C polymorphism related to connective tissue damage in young athletes were studied and it was investigated whether there was a difference in allele distribution in the athlete group related to connective tissue and muscle injury compared to the control group. Whether the allele distributions of the experimental and control groups were in balance was tested using the Hardy-Weinberg equation. Differences between groups were analyzed with Chi square Test. The confidence interval was determined as 95% (p<0.05). As a result of the research, no significant difference was found between the control group and athletes in terms of SLC16A1 gene A/T polymorphism (rs1049434). A significant difference was found between the athletes and the control group in terms of GDF5 gene T/C polymorphism (rs143383). CC and TC genotypes in athletes were more common than TT genotypes in individuals in the control group. This situation is in favor of athletes. As a result of the genotypes determined by studying the SLC16A1 and GDF5 gene polymorphisms in elite athlete groups within the scope of the research, coaches and club sports physicians can be informed and strategies can be developed to plan training to prevent injuries and to intervene in case of possible injury.
Keywords : Gen, Polimorfizm, Yaralanma, SLC16A1 MCT1, GDF5