18F-fluorodeoxyglucose positron emission tomography/computed tomography findings of breast cancer with signet ring cell differentiation: A single-center experience

Authors : Göksel ALÇIN, Esra ARSLAN

Pages : 303-312

Doi:10.21673/anadoluklin.1341711

View : 24 | Download : 38

Publication Date : 2023-09-28

Article Type : Research Paper

Abstract :Aim: Due to the low incidence of breast cancer with signet ring cell insert ignore into journalissuearticles values(SRC); differentiation, which constitutes less than 1% of all breast cancers, little is known about its imaging features. The aim of this study was to evaluate the utility of 18F-Fluorodeoxyglucose insert ignore into journalissuearticles values(18F-FDG); Positron Emission Tomography/Computed Tomography insert ignore into journalissuearticles values(PET/CT); in staging breast cancer with SRC differentiation. Methods: We conducted a retrospective analysis of 14 patients with histologically confirmed breast cancer with SRC differentiation who underwent 18F-FDG PET/CT at our institution between 2014 and 2023. The imaging findings were analyzed in terms of maximum standardized uptake value insert ignore into journalissuearticles values(SUVmax);, lesion size, and the presence of regional or distant metastases were statistically evaluated. Results: The histological subtypes of SRC differentiated primary tumors were 9 invasive lobular, and 5 invasive ductal carcinoma. More intense 18F-FDG uptake was observed in primary tumoral lesions of the ductal subtype insert ignore into journalissuearticles values(mean SUVmax: 18.8±9.8; range: 2.6–28.9); compared to the lobular subtype insert ignore into journalissuearticles values(mean SUVmax: 2.6±1.3; range: 1.5–5.1); insert ignore into journalissuearticles values(p=0.007, Z=2.600);. Among the patients included in the study, axillary lymph node metastasis was present in 64% insert ignore into journalissuearticles values(n=9); of the cases, with lymph node metastasis identified in five cases classified as ductal carcinoma. Additionally, distant organ metastasis was identified in 21% insert ignore into journalissuearticles values(n=3); of patients, comprising two patients with ductal carcinoma and one with lobular carcinoma. Conclusion: Despite the general consensus that signet-ring cell tumors have a low affinity for 18F-FDG, our study has observed the possibility of high 18F-FDG uptake in cases of ductal carcinoma. However, in cases of lobular carcinoma, where 18F-FDG uptake tends to be low, considering alternative PET radiopharmaceuticals for imaging could be a viable option.
Keywords : Fluorodeoksiglukoz F18, meme kanseri, pozitron emisyon tomografi, bilgisayarlı tomografi, taşlı yüzük hücreli karsinom