Investigation of the relationship between glucose potassium ratio and insulin resistance in polycystic ovary syndrome infertile women

Authors : Naziye Gürkan

Pages : 120-126

Doi:10.21673/anadoluklin.1183228

View : 63 | Download : 57

Publication Date : 2024-05-29

Article Type : Research Paper

Abstract :Aim: The aim of this study was to evaluate the relationships between glucose potassium (Glu/K+) ratio and insulin resistance (IR) in infertile women with polycystic ovary syndrome (PCOS). It is necessary to identify a new diagnostic parameter such as Glu/K+ ratio for IR in PCOS patients. Methods: A total of 198 reproductive-aged women were included in this retrospective case–control study. Women aged 20-39 years diagnosed with infertility and PCOS constituted the PCOS group. Women who were diagnosed with infertility but not PCOS formed the control group. Result: The age and body mass index (BMI) of the participants were 30.31±4.68 and 26.53±4.80, respectively. Fasting blood glucose was found to be higher in those with a diagnosis of PCOS (p<0.05). Homeostatic model assessment for insulin resistance (HOMA-IR) and fasting insulin were found to be higher in those with a diagnosis of PCOS (p<0.05). Serum Glu/K+ ratio was found to be higher in those diagnosed with PCOS (p<0.05). A positive correlation was found between fasting insulin and Glu/K+ ratio in PCOS women (p<0.05). The area under the ROC curve for the Glu/K+ ratio was found to be 0.719, close to the insulin. Conclusion: Our outcomes indicate that the serum Glu/K+ ratio is favorable and closely related to insulin, which has diagnostic properties for PCOS. We believe the serum Glu/K+ ratio may be a valuable biomarker for insulin resistance in PCOS.
Keywords : Glukoz, insulin rezistansı, potasyum, polikistik over sendromu

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