The clinical value of complete blood count-based immun parameter in predicting testicular cancer pathology and prognosis

Authors : Muhammed Fatih Şimşekoğlu, Ahmet Vural, Mustafa Macit, Fatih Yıldız, Göktuğ Kalender, Uğur Aferin, Mehmet Hamza Gültekin, Çetin Demirdağ

Pages : 210-216

Doi:10.21673/anadoluklin.1400323

View : 26 | Download : 36

Publication Date : 2024-05-29

Article Type : Research Paper

Abstract :Aim: The management of testicular cancer (TC) requires more specific and applicable biomarkers. We aimed to determine the ability of complete blood count (CBC) based inflammatory markers to predict tumor pathology and prognosis in TC. Methods: Patients who underwent inguinal orchiectomy for testicular germ cell tumors (TGCTs) at our hospital between January 2011 and December 2022 were included in the study. The medical records of patients with pathologically confirmed TC, including demographics, preoperative tumor markers, preoperative CBC, tumor characteristics, pathological outcomes, postoperative follow-up, and survival outcomes, were retrospectively collected. CBC-based inflammatory markers were compared between seminomatous and non-seminomatous TGCTs. To determine the independent prognostic significance of survival, the data were analyzed and fitted to the multivariate Cox proportional risk regression model. Results: The median follow-up was 48 (1-140) months. In our chord, 69 patients had seminomatous TGCTs (Group 1), and 66 had non-seminomatous TGCTs (Group 2). The median ages of Groups 1 and 2 were 35 (22-74) years and 31 (21-72) years(p<0,05). The median platelet count (PC) was 238 (136-377) 10³/mm³ in Group 1, and 260,5 (158-414) 10³/mm³ in Group 2 (p<0.05). The median neutrophil count (p=0.75), monocyte count (MC) (p=0.762), lymphocyte count (LC) (p=0.726), neutrophil-to-lymphocyte ratio (p=0.128), platelet-to-lymphocyte ratio (p=0.201), and lymphocyte-to-monocyte ratio (p=0.782) there was no statistically significant difference between seminomatous and non-seminomatous TGCTs. A higher median systemic immune-inflammation index (SII) was statistically significantly associated with non-seminomatous TGCTs. Multivariate Cox regression analysis revealed that high PC and MC values and a low LC value were independently correlated with worse overall survival. Conclusions: High PC and SII levels are associated with non-seminomatous TGCTs. However, SII is not associated with survival outcomes. Unlike the remaining parameters, high PC and MC and low LC were found to have independent prognostic effects on worse overall survival.
Keywords : İnflamasyon mediyatörleri, patoloji, testis kanseri