Exploring the relationship between berberine and the gut microbiome: A closer look at recent studies

Authors : Damla Beyazgül, Nuray Esra Aksakal

Pages : 372-386

Doi:10.21673/anadoluklin.1410170

View : 207 | Download : 214

Publication Date : 2024-09-23

Article Type : Review Paper

Abstract :Aim: Berberine, known for regulating blood glucose and reducing inflammation, also enhances gut microbiota diversity and repairs microbial profiles. However, comprehensive reviews on its disease-specific impacts are limited. This study aims to explore berberine’s influence on microbiota diversity in various diseases, offering a novel perspective. Methods: A literature review was conducted using PubMed, Web of Science, ScienceDirect, and Google Scholar, focusing on studies from 2018-2023. Keywords related to berberine and gut microbiota were used, excluding irrelevant topics. A total of 84 titles and abstracts were screened, with 33 articles meeting inclusion criteria for detailed review. Results: Berberine promotes beneficial species like Bacteroidetes and Akkermansia, shows antimicrobial properties, and targets specific pathogens. Studies, particularly in obese and Type 2 diabetic mice, suggest it can improve gut microbiota and diversity. However, the optimal dosage remains unclear, and individual microbial responses can vary, sometimes leading to dysbiotic profiles. Conclusion: Berberine shows promise in enhancing gut microbiota diversity and combating pathogens. Nevertheless, further studies are needed to confirm its therapeutic potential and establish optimal treatment protocols with long-term clinical outcomes.
Keywords : Berberin, mikrobiyota, mikrobiyal, mikrobiyom