Investigation of Toxicity and Pharmacokinetic Profiles of Some Frequently Used Drugs in the Emergency Departments

Authors : Serhat Karaman

Pages : 203-208

Doi:10.46810/tdfd.1603524

View : 50 | Download : 154

Publication Date : 2025-12-30

Article Type : Research Paper

Abstract :In this paper, pharmacokinetic profiles and toxicity values, also known as ADME parameters, for some drugs frequently used in hospital emergency services, such as Thiocolchicoside, Pheniramine maleate, Captopril, Dexketoprofen, and Paracetamol, were obtained by in silico research methods. With the study results, some critical parameters, such as intestinal-renal absorption of drugs, effects on the central nervous system, binding percentages to plasma proteins, and pure water solubility, were determined. In addition, organ and cell toxicities of each drug were determined in silico, and LD50 values were reported. According to the obtained results, the highest HIA absorption drug is dexketoprofen. Also, paracetamol has the greatest diffusion throughout the circulatory system between all drugs. Finally, the highest LD50 values are obtained for Captopril (2078 mg/kg) and Pheniramine maleate (343 mg/kg).
Keywords : Sık kullanılan önemli acil servis ilaçları, in silico tahminler, ADMET, Toksisite

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