Thyroid hormones as a potential prognostic markers for neonates with hypoxic ischemic encephalopathy

Authors : Gaffari TUNÇ, Nurullah ÇELİK, Fatih KILIÇBAY, Mahmut EKİCİ

Pages : 246-253

Doi:10.51972/tfsd.1124883

View : 21 | Download : 8

Publication Date : 2022-09-30

Article Type : Research Paper

Abstract :BACKGROUND: Hypoxic ischemic encephalopathy insert ignore into journalissuearticles values(HIE); is one of the most important causes of mortality and morbidity in newborns. Few studies with conflicting results have been conducted on the effect of perinatal asphyxia and thyroid hormones METHODS: A total of 96 newborns insert ignore into journalissuearticles values(46 patients with HIE and 50 controls); were included in the study. Electroencephalography insert ignore into journalissuearticles values(EEG); results, cranial magnetic resonance imaging insert ignore into journalissuearticles values(MRI);, magnetic resonance spectroscopy insert ignore into journalissuearticles values(MRS);, Sarnat Stages, and the presence of seizures of the HIE group were recorded. Thyroid-stimulating hormone insert ignore into journalissuearticles values(TSH); and free thyroxine insert ignore into journalissuearticles values(fT4); levels of all cases were also measured between 5-10 days. Patients with HIE were separated into 3 groups according to the fT4 insert ignore into journalissuearticles values(≤1.52 ng / dL, 1.52-1.84 ng / dL, and ≥1.84 ng / dL);, and TSH insert ignore into journalissuearticles values(≤2.56 IU / mL. 2.56-5.3 1IU / Ml, and ≥5.31 IU / mL); levels. RESULTS: All the newborns with seizures were in the 1st or 2nd tertiles of fT4, none of those with high fT4 insert ignore into journalissuearticles values(>1.84 ng/dL);, and the difference was statistically significant insert ignore into journalissuearticles values(x2=6.61; p=0.036);. A negative correlation was determined between fT4 level and duration of hospitalization insert ignore into journalissuearticles values(=-0.43; p=0.03);, duration of respiratory support insert ignore into journalissuearticles values(r=-0.32; p=0.029);, duration of intubation insert ignore into journalissuearticles values(r=-0.40; p=0.006);, and time to full oral feeding insert ignore into journalissuearticles values(r=-0.40; p=0.006);. The TSH level was only correlated with the duration of hospitalization insert ignore into journalissuearticles values(r=-0.34, p=0.02);. CONCLUSIONS: Free T4 level may be used as a prognostic marker in newborns with HIE. Further multicenter, larger, and prospective studies are needed to support and confirm these findings.
Keywords : Newborn, Hypoxic ischemic encephalopathy, Hypothermia, Thyroid hormones