Reasons For Requesting the Test in Antinuclear Antibody-Positive Patients and Final Diagnosis of Patients

Authors : Nimet ÖNER, Elif ÇELİKEL, Zahide EKİCİ TEKİN, Vildan GÜNGÖRER, Serkan COŞKUN, Melike Mehveş KAPLAN, Cüneyt KARAGÖL, Nilüfer TEKGÖZ, Müge SEZER, Merve Cansu POLAT, Banu ACAR

Pages : 347-353

Doi:10.12956/tchd.1266045

View : 110 | Download : 166

Publication Date : 2023-09-25

Article Type : Research Paper

Abstract :Background: The aim of this study was to determine the reasons for the request for antinuclear antibody insert ignore into journalissuearticles values(ANA); in ANA-positive patients and to determine the final diagnosis of these patients and whether they developed a rheumatologic disease. Method: In this retrospective study, the files of 559 patients with positive ANA were reviewed. Demographic, laboratory and clinical characteristics of the patients were noted. At the end of follow-up, the final diagnosis was recorded. Results: The study included 346 patients. 233 of the patients were female, and 113 were male. The mean age at the time of ANA positivity was 9.4  4.7 years, and the mean follow-up period was 19  5.7 months. The most common symptom was myalgia/arthralgia insert ignore into journalissuearticles values(21.7%);. Other common reasons were urticaria, abdominal pain, thrombocytopenia, and proteinuria. Extractable nuclear antigens insert ignore into journalissuearticles values(ENA); panel results were negative in 170 patients insert ignore into journalissuearticles values(49.1%);. In the ENA panel, dense fine speckled antigen 70 antibodies were most frequently positive in 135 patients insert ignore into journalissuearticles values(39.2%);. At the end of follow-up, 234 patients had no disease. One hundred and one patients were diagnosed with non-rheumatologic diseases, and 11 patients were diagnosed with rheumatologic diseases. Eleven patients with rheumatologic diseases were girls. Rash was the most common symptom in patients with rheumatologic diseases. The positive predictive value of ANA positivity for rheumatologic disease was 3.2% and 1.7% for systemic lupus erythematosus. Conclusions: Due to the low positive predictive value of ANA testing, patients at risk for autoimmune diseases should be identified and carefully evaluated before ANA is requested.
Keywords : Antinükleer antikor, DFS 70, Sistemik lupus eritematozus

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