Effects of sequential and fixed-dose estradiol valerate administration on premature progesterone rise in frozen-thawed embryo transfer cycles

Authors : Ayşe Şeyma KÜÇÜKAKÇA, Mehmet AĞAR, Nur DOKUZEYLÜL GÜNGÖR, Tuğba GÜRBÜZ

Pages : 71-75

Doi:10.38053/acmj.1209514

View : 28 | Download : 11

Publication Date : 2023-01-20

Article Type : Research Paper

Abstract :Aim: This study investigated the risk of premature progesterone insert ignore into journalissuearticles values(P4); rise in the fixed and sequential estradiol valerate insert ignore into journalissuearticles values(EV); administration for frozen embryo transfer insert ignore into journalissuearticles values(FET); cycles. Material and Method: In this cross-sectional case-control study, 1272 cycles of FET were analyzed retrospectively from computer records between January 2015 to August 2020. EV was administrated in 795 patients with a fixed dose and in 477 patients with a sequential dose. P4 values were measured on the day when the endometrial thickness reached 8 mm in the patients. Results: There were 795 patients in the fixed EV administration group with a mean age of 30.75±3.39 and 477 patients in the sequential EV administration with a mean age of 30.75±3.39. P4 of the sequential-dose group insert ignore into journalissuearticles values(1.05±0.31); was significantly higher than the fixed-dose group insert ignore into journalissuearticles values(1.01±0.33);. The Pairwise Z-Tests found that the abort rate was significantly higher in the sequential-dose group insert ignore into journalissuearticles values(p=0.04);. Conclusion: Our results showed a higher P4 and abortion rate in the sequential-dose group. These findings show that premature P4 rise can be considered a risk factor.
Keywords : Estradiol valerate, progesterone, FET