The role of ADC histogram analysis in the diagnosis of pediatric malignant lymphadenopathy

Authors : Turgut SEBER, Tuğba UYLAR SEBER, Elif AKTAŞ, Fatma Türkan MUTLU, Veysel GÖK, Şuayip KESKİN, Fatoş TEKELİOĞLU, Arzu TASDEMİR

Pages : 91-96

Doi:10.38053/acmj.1240036

View : 16 | Download : 6

Publication Date : 2023-03-27

Article Type : Research Paper

Abstract :Aim: Lymphadenopathy insert ignore into journalissuearticles values(LAP); is one of the most common daily practice clinical findings in children. LAPs that involve more than one region and do not decrease with treatment are a significant cause of anxiety for clinicians and families. In this occurence, ultrasonography, which is the primary imaging method, is insufficient in some cases. Our aim is to make histopathological predictions with apparent diffusion coefficient insert ignore into journalissuearticles values(ADC); histogram analysis. Material and Method: A total of thirty-one patients, seventeen male and fourteen female, who underwent magnetic resonance imaging and were diagnosed histopathologically insert ignore into journalissuearticles values(with tru-cut or excisional biopsy); were included in our study. Magnetic resonance imagings were evaluated retrospectively. Results: We could not differentiate lymphoma insert ignore into journalissuearticles values(when considered as a single group);, granulomatous LAP and reactive lymphoid hyperplasia with an ADC histogram analysis insert ignore into journalissuearticles values(p>0.05);. However, when the lymphoma subgroups were evaluated separately, we could only distinguish Burkitt’s lymphoma insert ignore into journalissuearticles values(with ADCmin values); from other pathologies insert ignore into journalissuearticles values(p<0.05);. The optimal cut-off value distinguishing Burkitt’s lymphoma from other groups was 245×10-6 mm2/sec in receiver operating characteristic curve analysis insert ignore into journalissuearticles values(AUC 0.981, sensitivity 75%, specificity 93%, PPV 67%, NPV 93%);. As in recent studies, we did not find significant differences in ADC histogram analysis values of reactive lymphoid hyperplasia, granulomatous LAPs and lymphomas insert ignore into journalissuearticles values(when considered as a single group);. However, when the lymphoma subgroups were considered separately, we were able to distinguish Burkitt’s lymphoma from other subgroups and granulomatous LAP, reactive lymphoid hyperplasia with the ADCmin value. Conclusion: The ADCmin value in pediatric LAPs may contribute to the diagnosis of Burkitt’s lymphoma.
Keywords : Lymphadenopathy, pediatric, magnetic resonance imaging, histogram analysis, apparent diffusion coefficient, Lymphadenopathy, magnetic resonance imaging, histogram analysis, apparent diffusion coefficient