The relationship between the prognostic nutritional index and non-dipping blood pressure pattern in patients with newly diagnosed hypertension

Authors : Tufan GÜNAY, Selvi COŞAR

Pages : 287-294

Doi:10.38053/acmj.1258111

View : 59 | Download : 75

Publication Date : 2023-07-28

Article Type : Research Paper

Abstract :Aims: It has been suggested that immuno-nutritional status may play a role in blood pressure insert ignore into journalissuearticles values(BP); variations. This study aimed to investigate whether prognostic nutritional index insert ignore into journalissuearticles values(PNI); values differ between normotensive individuals and patients with newly diagnosed untreated hypertension insert ignore into journalissuearticles values(NDHT); and to clarify the relationship between the PNI and circadian BP patterns in NDHT patients. Methods: This retrospective study included 328 adult participants, comprising 164 NDHT patients and 164 normotensive individuals. The non-dipper BP pattern insert ignore into journalissuearticles values(NDP); was defined as a nighttime decline in BP of less than 10%. The PNI was calculated using the following formula: PNI=insert ignore into journalissuearticles values([10 × serum albumin insert ignore into journalissuearticles values(g/dL);] + [0.005 × total lymphocyte count]);. Results: The mean PNI value was lower in the NDHT group than the normotensive group insert ignore into journalissuearticles values(53.6±6.1 vs. 58.2±5.3, p<0.001);. There was a positive correlation between the PNI and the decline in nighttime BP levels insert ignore into journalissuearticles values(r=0.517; p<0.001);. NDP was identified in 45.1% insert ignore into journalissuearticles values(n=74); of the NDHT patients. The mean PNI value was lower in the NDP group compared to the dipper BP group insert ignore into journalissuearticles values(49.9±5.6 vs. 56.6±4.8, p<0.001);. Decreased PNI was an independent predictor of NDP insert ignore into journalissuearticles values(OR=0.70, 95% CI=0.61-0.81, p<0.001);. The cut-off value of the PNI in predicting NDP was established as ≤51.3 with 72.4% sensitivity and 69.8% specificity. Conclusion: Patients with hypertension had poorer immuno-nutritional statuses and a low PNI value was an important predictor of NDP. The PNI may be a useful screening tool for circadian BP patterns in patients with NDP.
Keywords : Circadian rhythm, hypertension, nutritional status, prognostic nutritional index