Thymoma radiotherapy: a retrospective multicentre study

Authors : İpek Pınar ARAL, Gonca ALTINIŞIK İNAN, Fatma Betül AYRAK, Feyza YAŞAR DAŞGIN, Nalan ASLAN, Yillar LEHİMCİOĞLU, Fatma YILDIRIM, Muhammed Bülent AKINCI, Yılmaz TEZCAN

Pages : 295-304

Doi:10.38053/acmj.1298365

View : 129 | Download : 119

Publication Date : 2023-07-28

Article Type : Research Paper

Abstract :Aims: In this study, we aimed to evaluate the outcomes of thymoma patients who underwent radiotherapy insert ignore into journalissuearticles values(RT);. Methods: Data from thymoma patients who underwent RT at Ankara Bilkent City Hospital, Ankara Atatürk Education and Research Hospital and Ankara Numune Education and Research Hospital were analysed retrospectively. The primary endpoints of this study were acute and late side effects and the secondary endpoints were overall survivalinsert ignore into journalissuearticles values(OS); and disease-free survivalinsert ignore into journalissuearticles values(DFS);. Results: Data from 22 patients who received RT between 10.03.2008 and 05.10.2022 were analysed.The median follow-up time was 33 months insert ignore into journalissuearticles values(range: 1–76);. RT-related acute toxicity was observed in 6 patientsinsert ignore into journalissuearticles values(27.3%);. Late RT-related toxicity was noted in 4 patients insert ignore into journalissuearticles values(18%);. As a late toxicity one patient insert ignore into journalissuearticles values(4.5%); had a secondary malignancy five years after RT.Patients younger than 40 years of age had significantly higher acute insert ignore into journalissuearticles values(p=0.039); and late insert ignore into journalissuearticles values(p=0.01); toxicity. Recurrence was observed in 7 patients insert ignore into journalissuearticles values(31.8%);. The median DFS was 13 months insert ignore into journalissuearticles values(range: 1–176);,the 1-year DFS was 58%, the 5-year DFS was 23%. Lower DFS was observed in patients with myasthenia gravis insert ignore into journalissuearticles values(MG); insert ignore into journalissuearticles values(p=0.018);. Six patientsinsert ignore into journalissuearticles values(27.3%); died, the median OS was 33 months insert ignore into journalissuearticles values(range: 1–176);,the 1-year OS was 84.4%, the 5-year OS was 76.7%. There was a significant correlation between performans status and OS insert ignore into journalissuearticles values(p=0.047);. Conclusion: Side effects were more frequently observed in patients younger than 40 years of age. Poor prognostic factors were identified as MG for DFS and poor performance status for OS. Thymoma patients have high OS, studies are needed to identify subgroups that do not require RT.
Keywords : Thymic epithelial tumours, radiotherapy, thymic carcinoma, thymoma

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