Tau protein hyperphosphorylation in children with cerebral palsy with sleep disorders

Authors : Ayşe Gülşen DOĞAN, İhsan ÇETİN

Pages : 270-274

Doi:10.38053/acmj.1309367

View : 75 | Download : 56

Publication Date : 2023-07-28

Article Type : Research Paper

Abstract :Aims: In this study, we aimed to evaluate the relationship between sleep disorder and serum tau protein levels in children with cerebral palsy. Methods: The sample was selected among children aged 6-10 years who applied to our physical medicine and rehabilitation outpatient clinic. In order to evaluate sleep quality, the Pittsburgh Sleep Quality Index insert ignore into journalissuearticles values(PSQI); questionnaire was recorded by asking parents of all participants. Children with CP who had a Pittsburgh Sleep Quality Index value above 5 were determined as the sleep disorder group. We recruited 27 children with CP and sleep disorders in the first patient group insert ignore into journalissuearticles values(Group 1);, 27 children with CP but without sleep disorders in the second group insert ignore into journalissuearticles values(Group 2);. The third group insert ignore into journalissuearticles values(Group 3);, which was the healthy group, included 27 children without any disease. We also recorded the age of children at diagnosis, risk factors for CP insert ignore into journalissuearticles values(premature, prolonged birth, etc.);, CP type, gross motor function classification system insert ignore into journalissuearticles values(GMFCS);, botox application, orthoses usage, maternal age at birth, and additional problems. We measured total tau protein insert ignore into journalissuearticles values(T-tau); and phosphorylated tau protein insert ignore into journalissuearticles values(P-tau); levels in blood samples through a double-antibody sandwich enzyme-linked immunosorbent assay insert ignore into journalissuearticles values(ELISA);. The correlation between tau protein and PSQI values was examined. Results: Maternal age insert ignore into journalissuearticles values(p=0.001);, gross motor function classification system insert ignore into journalissuearticles values(GMFCS); insert ignore into journalissuearticles values(p=0.001);, and pittsburgh sleep quality index insert ignore into journalissuearticles values(PSQI); insert ignore into journalissuearticles values(p=0.001); were significantly higher in the group with sleep disorders. There was a statistically significant difference between the groups in terms of serum T-Tau and P-tau protein levels insert ignore into journalissuearticles values(T-tau p=0.003, P-tau p=0.004);. In the group sleep disorders, PSQI was significantly correlated with T-tau insert ignore into journalissuearticles values(r=0.499); and P-tau insert ignore into journalissuearticles values(r=0.473);. Conclusion: This study shows that tau protein levels are higher in CP patients with sleep disorders than in participants without sleep disorders. In the correlation analyzes, a positive and significant correlation was observed between PSQI values and T-tau and P-tau in sleep disorders groups, and no correlation was found in without sleep disorders.
Keywords : serebral palsi, tau protein, hiperfosforilize tau protein, uyku bozukluğu