Perinatal Outcomes in Pregnancies Diagnosed with Intrahepatic Cholestasis: A Retrospective Analysis Based on the Last Three Years of Data

Authors : Mustafa Raşit Özler, Serenat Yalçın, Erkan Sağlam, Ebu Bekir Siddik Yilmaz, Beyda Taşkesen

Pages : 427-433

Doi:10.32708/uutfd.1704459

View : 54 | Download : 181

Publication Date : 2025-12-08

Article Type : Research Paper

Abstract :This retrospective cohort study aimed to evaluate maternal and neonatal outcomes in pregnancies complicated by intrahepatic cholestasis of pregnancy (ICP) and to compare them with matched healthy controls. A total of 70 women diagnosed with ICP and 240 controls matched for age, parity, and year were included. All participants were followed at a tertiary care center in Turkey between January 2022 and January 2025. Maternal demographics, laboratory results, obstetric characteristics, and neonatal outcomes were assessed. Subgroup analyses were conducted according to the severity of bile acid elevation and the timing of ICP diagnosis (early vs. late onset). The presence of ICP was significantly associated with increased rates of preterm delivery (35.7% vs. 5.8%, p<0.001), lower birth weight (2888±371 g vs. 3295±467 g, p<0.001), higher NICU admission (30% vs. 7.9%, p<0.001), and reduced Apgar scores. Severe ICP (≥100 μmol/L) correlated with earlier delivery and a higher incidence of low birth weight (71.4%, p<0.001). Early-onset ICP was linked to a higher frequency of meconium-stained amniotic fluid and lower cord pH levels. Although ursodeoxycholic acid (UDCA) therapy was commonly administered, clinical response remained limited in severe and early-onset cases. In conclusion, ICP is significantly associated with adverse perinatal outcomes, particularly when presenting early or with severe bile acid elevation. Early diagnosis, close monitoring of bile acid levels, and individualized management strategies may help reduce fetal risks. Further prospective studies are warranted to clarify diagnostic thresholds and optimize the timing of delivery.
Keywords : Gebelik kolestazı, Safra asitleri, Erken doğum, Yenidoğan sonuçları, Perinatal morbidite

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