The Therapeutic Role and Survival Impact of Systematic Lymphadenectomy in Endometrial Cancer: A Retrospective Cohort Study

Authors : Yakup Yalcin, Kemal Özerkan
Pages : 475-481
Doi:10.32708/uutfd.1774928
View : 27 | Download : 113
Publication Date : 2025-12-08
Article Type : Research Paper
Abstract :The aim of this study was to evaluate the therapeutic and prognostic role of systematic lymphadenectomy in patients with endometrioid endometrial cancer. The study included 512 patients with FIGO 2009 stage I-III endometrioid endometrial carcinoma who underwent primary surgical treatment at a tertiary university hospital between January 2010 and May 2025. Patients were categorized according to whether lymphadenectomy was performed. Clinicopathological features, disease-free survival (DFS), and overall survival (OS) were compared. Survival outcomes were estimated using Kaplan–Meier analysis and log-rank tests, and prognostic factors were identified using Cox proportional hazards regression. Of the total cohort, 407 patients (79.5%) underwent lymphadenectomy and 105 (20.5%) did not. The lymphadenectomy group more frequently exhibited adverse pathological features, including larger tumor size, high-grade histology, deep myometrial invasion, and LVSI (all p<0.01). After a median follow-up of 68 months, recurrence rates were comparable between the groups (7.9% vs. 6.7%, p=0.837). The estimated 5-year DFS rates were 92.5% for the lymphadenectomy group and 92.1% for the non-lymphadenectomy group. The 5-year OS rates were 83.2% and 87.5%, respectively. Lymphadenectomy was not associated with improved DFS (HR 1.31, 95% CI 0.58–2.96, p=0.547) or OS (HR 1.42, 95% CI 0.81–2.47, p=0.199). Multivariable analysis identified age, tumor grade, and LVSI as independent predictors of recurrence and survival, whereas lymphadenectomy was not an independent prognostic factor. Systematic lymphadenectomy does not confer a survival benefit in endometrioid endometrial cancer. Tumor biology, rather than the extent of nodal dissection, appears to be the dominant determinant of oncologic outcomes.
Keywords : Endometriyal Kanser, Genel Sağkalım, Hastalıksız Sağkalım, Lenfadenektomi.

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