Can Triglyceride/Glucose Index (TyG) and Triglyceride/HDL-Cholesterol Ratio (TG/HDL-c) Predict Gestational Diabetes Mellitus?

Authors : Seval YILMAZ ERGANİ, Tolgay Tuyan İLHAN, Betül TOKGÖZ, Burak BAYRAKTAR, Mevlüt BUCAK, Müjde Can İBANOĞLU, Kadriye YAKUT YÜCEL, Kadriye ERDOĞAN, Cantekin İSKENDER, Yaprak ÜSTÜN

Pages : 117-120

Doi:10.20492/aeahtd.1327956

View : 81 | Download : 87

Publication Date : 2023-09-30

Article Type : Research Paper

Abstract :AIM: We investigated whether measurement of triglyceride/glucose index insert ignore into journalissuearticles values(TyG); and triglyceride/HDL-cholesterol ratio insert ignore into journalissuearticles values(TG /HDL-c); in the first trimester can predict gestational diabetes mellitus insert ignore into journalissuearticles values(GDM);. MATERIAL AND METHOD: Twenty-five patients with GDM and 52 women without GDM with normal glycemic control during pregnancy were included in the study as a control group. Both insulin-controlled diabetes and diet-controlled diabetes were included in the diagnosis of GDM. Fasting glucose and plasma lipid profiles including TG, HDL-c, TyG index, and TG /HDL-c measured in the first trimester were analyzed. RESULTS: Triglyceride values insert ignore into journalissuearticles values(mean 133±40 mg/dL in the gestational diabetes group, 100±54 mg/dL in the control group);, TyG index insert ignore into journalissuearticles values(15.0±8.9 in the mean gestational diabetes group, 8.8±5.0 in the control group);, and TG/HDL-C ratio insert ignore into journalissuearticles values(mean 3.3±2.6 in the gestational diabetes group and 1.9±2.6 in the control group); was found to be significantly higher in the GDM group insert ignore into journalissuearticles values(p=0.01, p=0.01, p=0.01, respectively);. The optimal cutoff value for TyG index was 10.4, sensitivity was 76%, specificity was 77%, and area under the receiver characteristic curve insert ignore into journalissuearticles values(AUC); was 0.765 to predict GDM insert ignore into journalissuearticles values(p < 0.001);. The optimal cutoff value for the TG /HDL-C ratio was 2.3, sensitivity was 76%, specificity was 69, AUC 0.697 to predict GDM insert ignore into journalissuearticles values(p=0.005);. CONCLUSION: TyG and TG/HDL-C ratio measured in the first trimester are thought to predict GDM better than fasting plasma glucose.
Keywords : Gestasyonel diabetes mellitus, birinci trimester, gebelik, Trigliserit Glikoz İndeksi, Trigliserit HDL Kolesterol Oranı