The role of inflammatory parameters in the management of cases with atypia of undetermined significance/follicular lesions of undetermined significance

Authors : Marlen SÜLEYMAN, Rıfat BEZİRCİ

Pages : 131-135

Doi:10.20492/aeahtd.1342736

View : 55 | Download : 52

Publication Date : 2023-09-30

Article Type : Research Paper

Abstract :AIM: This study aimed to evaluate the potential of hematologic parameters and markers such as neutrophil-lymphocyte ratio insert ignore into journalissuearticles values(NLR);, platelet-lymphocyte ratio insert ignore into journalissuearticles values(PLR);, monocyte-lymphocyte ratio insert ignore into journalissuearticles values(MLR);, systemic immune-inflammation index insert ignore into journalissuearticles values(SII);, and systemic inflammation response index insert ignore into journalissuearticles values(SIRI); to predict the risk of malignancy in patients whose biopsy results were classified as Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance insert ignore into journalissuearticles values(AUS/FLUS);. MATERIAL AND METHOD: A total of 188 patients who underwent thyroidectomy at a General Surgery clinic were included in the study. Hematological parameters, including neutrophil count, platelet count, lymphocyte count, monocyte count, and mean platelet volume insert ignore into journalissuearticles values(MPV); were collected from the hospital database. NLR, PLR, MLR, SII, and SIRI were calculated. Statistical analyses were performed using SPSS v25. RESULTS: 38 patient insert ignore into journalissuearticles values(20.21%); were male and 150 patients insert ignore into journalissuearticles values(79.79 %); were female. The mean age was 48.6 insert ignore into journalissuearticles values(range 23-79, standard deviation insert ignore into journalissuearticles values(SD); ± 12.41years);. Histopathological examination of the thyroidectomy specimens revealed benign findings in 102 patients insert ignore into journalissuearticles values(54.3%); and malignant findings in 86 patients insert ignore into journalissuearticles values(45.7%);. The mean age of the malignant group was 45.6, while that of the benign group was 51.1 insert ignore into journalissuearticles values(p = 0.02);. The median tumor size was 17 mm in the malignant group and 21 mm in the benign group insert ignore into journalissuearticles values(p =0.042);. Mean neutrophil count were 4.29 ± 1.0 × 109/L in the benign group and 4.69 ± 1.9 × 109/L in malignant group, respectively insert ignore into journalissuearticles values(p = 0.031);. NLR values were calculated as 1.89 for the benign group and 1.99 for the malignant group insert ignore into journalissuearticles values(p = 0.045);. SII values were higher in the malignant group, with a median value of 584.11× 109/L in the malignant group, median value were 504.63× 109/L in the benign group insert ignore into journalissuearticles values(p=0.037);. Multivariate logistic regression analysis revealed that both age insert ignore into journalissuearticles values(odds ratio insert ignore into journalissuearticles values(OR); = 0.964; 95% confidence interval insert ignore into journalissuearticles values(CI);= insert ignore into journalissuearticles values(0.939 – 0.989);; p = 0.05); and neutrophil count insert ignore into journalissuearticles values(odds ratio insert ignore into journalissuearticles values(OR); = 1.598; 95% confidence interval insert ignore into journalissuearticles values(CI);= insert ignore into journalissuearticles values(1.118 – 2.285);; p = 0.01); had a significant impact on the differentiation between benign and malignant thyroid nodules. CONCLUSION: Age and neutrophil count were identified as independent risk factors for malignant thyroid nodules. Among patients with Bethesda Category III thyroid nodules, those under 59.5 years of age and with a neutrophil count above 4.16 x 10^9/L have an increased risk for thyroid malignancy. Platelet count, monocyte count, MPV and inflammatory parameters, such as PLR, MLR, and SIRI, were insufficient for detecting malignancy in Bethesda III nodules. In this group, young age, small nodule size, high neutrophil count, NLR, and SII were identified as risk factors for malignancy. The Thyroid Imaging Reporting and Data System insert ignore into journalissuearticles values(TI-RADS); characteristics of nodules should also be considered in the management of these patients.
Keywords : Bethesda raporlama sistemi, Önemi belirsiz atipi önemi belirsiz foliküler lezyonlar, nodüller, Tiroid kanseri, biyobelirteç