Clinical characteristics of patients with ectopic pregnancies treated with repeated doses of methotrexate.

Authors : Sabri Kurtay, Murat Gözüküçük, Gamze Doğan Yangır, Yusuf Ustun

Pages : 49-52

Doi:10.20492/aeahtd.1371505

View : 109 | Download : 130

Publication Date : 2024-08-31

Article Type : Research Paper

Abstract :ABSTRACT Aim: Dose regimens of methotrexate used in the medical treatment of ectopic pregnancy vary. In this study, factors determining single-dose and repeated-dose methotrexate regimens were investigated. Material and methods: Patients diagnosed with ectopic pregnancy and treated with methotrexate in a tertiary care center were retrospectively analyzed. Medical characteristics, ultrasonography findings, and laboratory values of patients treated with single-dose methotrexate (n=128) and patients treated with additional doses (n=30) were compared. p<0.05 was considered significant. Results: There was no significant difference between the patient and medical characteristics. The need for additional dose was less in patients with more pelvic fluid on ultrasonography (p<0.001). Patients with a day 4/day 1 β-hcg ratio of 0.8474 and above required an additional dose of methotrexate (p<0.001). Discussion: Different parameters have been defined for patient selection for effective medical treatment of ectopic pregnancy. In this study, the effects of ultrasonography findings and β-hcg levels at follow-up on patient selection were quantitatively determined. Conclusion: The combination of day 4/day 1 β-hcg ratio and ultrasonography findings may help to identify patients in need of additional doses of methotrexate.
Keywords : Beta human koryonik godadotropin, Ektopik gebelik, Metotreksat