Risk-Reducing Surgeries in Gynecological Cancers: A Review of the Current State

Authors : Bilal Esat Temiz, Utku Akgör

Pages : 74-78

Doi:10.20492/aeahtd.1493135

View : 74 | Download : 94

Publication Date : 2024-08-31

Article Type : Review Paper

Abstract :Risk-reducing surgery has an important role to play in the prevention of gynaecological cancers, particularly in women who are at high risk of these cancers. Risk-reducing bilateral salpingo-oophorectomy (rrBSO) has been shown to significantly reduce the risk of ovarian and fallopian tube cancers and all-cause mortality in women with BRCA1/2 mutations. Combined prophylactic hysterectomy and bilateral salpingo-oophorectomy is recommended for patients with Lynch syndrome and has been shown to reduce the risk of endometrial and ovarian cancer. Although long-term data are needed, opportunistic salpingectomy is considered to be an effective method of reducing the risk of epithelial ovarian cancer. Based on genetic mutations and individual risk factors, risk-reducing surgery for gynaecological cancers is an important component of personalised treatment plans. The aim of this review is to provide a comprehensive analysis of the different surgical strategies associated with BRCA1/2 mutations, Lynch syndrome and other hereditary conditions. It evaluates the role and potential benefits of surgical interventions such as risk-reducing bilateral salpingo-oophorectomy (rrBSO), prophylactic hysterectomy and opportunistic salpingectomy in clinical practice, and assesses their efficacy and feasibility.
Keywords : risk azaltıcı cerrahiler, endometriyum kanseri, çift taraflı salpingo ooferektomi, kalıtsal kanser sendromları, yumurtalık kanseri