Is There Any Relationship between Clinical Progress and Vitamin-D Levels in Critically Ill Children?

Authors : Tuğçe Güzelkaş, Handan Alp

Pages : 105-109

Doi:10.20492/aeahtd.1447582

View : 16 | Download : 33

Publication Date : 2025-01-22

Article Type : Research Paper

Abstract :Introduction: Vitamin-D is a hormone that affects infections, the autoimmune system, the cardiovascular system, and the central nervous system; therefore, it is considered important for critically ill patients. This study aimed to examine the relationship between vitamin-D levels and Paediatric Risk of Mortality (PRISM)III score and mortality rates in critically ill children. Method: A total of 200 patients who were admitted to Atatürk University Paediatric Intensive Care Unit between January 2016 to January 2017 were included in this study. Demographic data, PRISM III score, serum calcium, phosphorus, alkaline phosphatase, parathormone, and 25-Hydroxy-Vitamin-D [25(OH)D] levels were recorded. 25(OH)D levels were grouped as deficiency (below 12 ng/ml), insufficiency (12-20 ng/ml), sufficiency (20-100 ng/ml), and excess (above 100 ng/ml). Results: Vitamin-D levels of 23.5% of the patients were deficient, 24.5% were insufficient, and 52% were sufficient. A negative correlation was found between vitamin-D and age (r=-0.42, p<0.01). PRISM III score was found to be lower in patients with sufficient vitamin-D (p<0.01). Although the mortality rate of cases with vitamin-D deficiency was higher, it was not found to be significant. No significant relationship was found between vitamin-D level and duration of hospitalization, duration of mechanical ventilation, chronic disease status, or vasopressor need. Conclusion: PRISM scoring system is a scoring system frequently used in paediatric intensive care units to predict mortality. The higher PRISM III score in patients with insufficient or deficient vitamin-D levels may suggest that vitamin-D insufficiency or deficiency is a risk factor for mortality.
Keywords : D vitamini, Mortalite, PRISM III, Kritik hasta çocuk