Antioxidant Contents and Oxidative Stress Markers in Pediatric Familial Mediterranean Fever

Authors : Amani Yasin, Halit Demir, Lokman Üstyol, Şükran Akgeyik, Rabia Akgeyik, Canan Demir

Pages : 17-39

Doi:10.52976/vansaglik.1535898

View : 66 | Download : 99

Publication Date : 2025-04-30

Article Type : Research Paper

Abstract :ABSTRACT: Objective: Familial Mediterranean fever (FMF) is a non-genomic latent pathosis delineated by iterative attacks of fever with serositis. Variants of the FMF gene (MEFV) have been detected predominantly in patients from Mediterranean inhabitants. This study contemplates demonstrating the activity of antioxidants and oxidative stress in children diagnosed with FMF. Material and Method: The study material comprised a range of 0-18 years of age of 35 individuals diagnosed with Familial Mediterranean Fever compared to 35 healthy participants. The study was conducted between 2016-2017. The samples were taken after the approval of Yüzüncü Yıl University, Medical Faculty of Research, education and Training Hospital, Department of Pediatric Health and Diseases Clinic and Research Laboratory Center. The studied enzymatic antioxidant activities as in (GSH, GPx, and SOD) and the malondialdehyde (MDA) level, which represents the end product of the lipid peroxidation process, the differences were revealed in the serum samples collected in distinction to patients diagnosed with FMF. The entirety of the analyses was conducted utilizing the SPSS statistics software package. Results: In the estimation activity of GSH for the sera of patients, insignificant divergence was noticed at the time contrasted with comparator groups. The patient groups exhibited SOD activity that was revealed to be notably lower versus the healthy control group, showing statistical significance (p<0.001). Besides, no significant difference in serum GPx activity was discerned relative to the control group. The serum malondialdehyde (MDA) concentration was significantly elevated compared to the control groups. The distinction in the averages of GSH and GPx enzymes was found to be statistically insignificant, whereas, the variance of MDA and SOD averages between the patient and control groups was found to be statistically significant (p<0.05). Hence, levels of MDA were elevated among the patients who endured Familial Mediterranean Fever disturbance. While, at the outset, the function of antioxidant enzymes such as SOD and GSH has shown a decline. Conclusion: As a result of these grounds, alternative methods ought to be demonstrated in clinical applications for FMF patients, antioxidant enzymes might alter the underlying causes of the disease and its etiopathogenesis. Consequently, from our findings, we inferred that the reason for the progress and advancement of Familial Mediterranean Fever (FMF) disease might be the outcome of disruption and Inequity among the levels of antioxidants and oxidative stress (OS).
Keywords : FMF, GSH, GPx, SOD and MDA.

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