Synthesis, Structural Elucidation and α-Glucosidase Inhibitory Activity of New Hydrazide Derivatives

Authors : Sevil Şenkardeş, Zeynep Hanne Baş

Pages : 69-77

Doi:10.53433/yyufbed.1613136

View : 31 | Download : 41

Publication Date : 2025-04-29

Article Type : Research Paper

Abstract :Diabetes mellitus (DM) is a chronic and progressive metabolic disorder affecting over 422 million people globally. It arises from insufficient insulin production or the inability of cells to respond to insulin, leading to disruptions in carbohydrate, fat, and protein metabolism. Over time, DM can result in severe complications such as cardiovascular diseases, kidney failure, and vision loss. Effective management of DM includes therapeutic strategies aimed at stabilizing blood glucose levels. Among these, α-glucosidase enzyme inhibitors play a crucial role by slowing carbohydrate digestion and reducing postprandial blood glucose spikes. In this study, new hydrazide derivatives linked to non-steroidal anti-inflammatory drugs (NSAIDs) were synthesized and evaluated as potential α-glucosidase enzyme inhibitors. Structural characterization of these derivatives was performed using techniques such as ¹H-NMR, FTIR, and mass spectrometry (MS). All of these compounds were tested in vitro for their α-glucosidase enzyme inhibition activity. Among the synthesized derivatives, ethyl 2-{3-[3-(trifluoromethyl)anilino]benzoyl}hydrazine-1-carboxylate (compound 3d), an etofenamate derivative, revealed the highest inhibitory potential with IC50 values of 188.30±0.1 μg mL-1 when compared with standard acarbose having IC50 value 190.70±2.05 μg mL-1. These findings highlight the potential of NSAID-linked hydrazide derivatives as promising candidates for the development of novel DM therapies.
Keywords : Diabetes Mellitus, Glukosidaz, Hidrazid, Karboksilat, NSAİİ