ELECTROCHEMICAL INVESTIGATION OF OTILONIUM BROMIDE USING BORON-DOPED DIAMOND AND GLASSY CARBON ELECTRODES

Authors : Leyla KARADURMUŞ, Esen Bellur ATİCİ, Sibel A ÖZKAN

Pages : 1003-1010

Doi:10.33483/jfpau.1344014

View : 58 | Download : 60

Publication Date : 2023-09-20

Article Type : Research Paper

Abstract :Objective: Using cyclic insert ignore into journalissuearticles values(CV); and differential pulse insert ignore into journalissuearticles values(DPV); voltammetric techniques, the electrochemical research of otilonium bromide insert ignore into journalissuearticles values(OTB); was carried out over a wide pH range insert ignore into journalissuearticles values(0.3–12); at glassy carbon electrodes insert ignore into journalissuearticles values(GCE); and boron-doped diamond electrodes insert ignore into journalissuearticles values(BDDE);. The typical electrochemical behavior of OTB was identified as being dependent on the type of working electrode and pH. This research aims to provide a brand-new electroanalytical technique for measuring OTB in buffer solutions. Material and Method: All experiments employed the typical three-electrode cell of 10 ml capacity in conjunction with a platinum wire counter electrode, a BDDE and GCE working electrode, and an Ag/AgCl reference electrode. NOVA 1.8 software and an AUTOLAB 204 potentiostat/galvanostat were used for electrochemical measurements. Result and Discussion: The electrochemical behavior of OTB, which belongs to a class of drugs called \`antispasmodics\` insert ignore into journalissuearticles values(spasm and cramps reliever);, primarily used to treat irritable bowel syndrome insert ignore into journalissuearticles values(IBS);, and other gastrointestinal conditions characterized by motility problems, painful bowel spasms and distension insert ignore into journalissuearticles values(swelling and bloating in the belly area);, was examined in 0.1 M H2SO4 at BDDE and GCE. The electrooxidation mechanism was also investigated by conducting CV investigations at various pH levels throughout a broad pH range insert ignore into journalissuearticles values(pH 0.3-12.0);. Understanding the mechanism was aided by scan rate investigations, which revealed that diffusion was controlled for both electrodes. The proposed technique was successfully used to determine OTB under optimal conditions.
Keywords : Bor katkılı elmas elektrot, camsı karbon elektrot, diferansiyel puls voltammetrisi, ilaç analizi, Otilonyum bromür