Histological investigation of the wound healing effects of Lucilia sericata (Meigen, 1826) (Diptera: Calliphoridae) larvae and Centaurea depressa M. Bieb. (Asteraceae)

Authors : Nevra Polat, Salih Mollahaliloğlu, Murat Koç, Hatice Baş

Pages : 150-156

View : 114 | Download : 328

Publication Date : 2025-11-15

Article Type : Research Paper

Abstract :Chronic wounds are a clinical problem characterised by disruption of the standard healing process (usually 4-12 weeks), reducing quality of life and placing a significant burden on the healthcare system. Metabolic diseases such as diabetes can cause chronic wounds. In the treatment of chronic wounds, complementary treatment approaches can be used alongside modern medical treatments. Maggot Debridement Therapy (MDT) is an effective method used worldwide for chronic wounds. The most commonly used species in MDT treatment is Lucilia sericata. Larval secretion products have antifungal, anti-inflammatory and antibacterial effects. Herbal treatments are also used in chronic wound care. Many species of the genus Centaurea have long been used in traditional medicine for various purposes. In this study, L. sericata larvae and the phytotherapeutic agent C. depressa plant extract were applied to treatment groups and their effects on wound healing were evaluated. For this purpose, 4 groups were created and maggot and plant extract were applied to the animals with diabetes. Histological studies, wound measurements, wound area and contraction values were measured to see the effect of the applications.According to wound measurements (area and contraction findings) and histological findings, plant extract and maggot treatment had positive effects on wound healing process. When maggot application was compared with plant extract application, it was seen that maggot application had more positive effects. However, it has been observed that their effects increase even more when used in combination.The main starting point is that the wound healing activity of the studied species in the chronic wound model has not been evaluated comparatively and combined before. As a result of this study, it was observed that C. depressa and L. sericata had positive effects on wound healing. It is thought that the data obtained may contribute to integrative medicine practices.
Keywords : Maggot, Lucilia sericata, Centaurea depressa, Diabetes mellitus, yara iyileşmesi

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