Effect of Postoperative Administration of Hyaluronic Acid/Trehalose Drop on Corneal Healing After Phacoemulsification Surgery

Authors : Hakika ERDOGAN, Orkun MUHSİNOGLU

Pages : 17-21

Doi:10.19127/bshealthscience.788064

View : 24 | Download : 9

Publication Date : 2021-01-01

Article Type : Research Paper

Abstract :This study aimed to evaluate the efficacy of hyaluronic acid/trehalose drop for corneal epithelial and stromal healing after phacoemulsification surgery at Maltepe University, Department of Ophthalmology, Istanbul, Turkey. It is a retrospective randomized comparative study.The patients had phacoemulsification surgery divided into two groups. These patients received either a mixture of sodium hyaluronate and trehalose insert ignore into journalissuearticles values(HT, Thealoz Duo®, Thea);insert ignore into journalissuearticles values(Group 1); or sodium hyaluronate 0.15% insert ignore into journalissuearticles values(Eye Still®; Teka); insert ignore into journalissuearticles values(Group 2); postoperatively. Effect on corneal epithelial and stromal healing was evaluated using Oxford staining and the vertical scar length measured by optic coherence tomography insert ignore into journalissuearticles values(OCT); respectively. Preoperative and postoperative findings for Oxford staining, Schirmer’s test, tear film break-uptime insert ignore into journalissuearticles values(TBUT); and ocular surface disease indexinsert ignore into journalissuearticles values(OSDI); scores were also evaluated. The correlation between scar length and tear film parameters was examined. The effect of trehalose on the epithelial healing and stromal scar formation was evaluated. Group 1 and 2 each had 30 eyes. The two groups were similar according to age and sex distribution. In terms of epithelial healing, it was faster in the trehalose group, although there was no statistical difference between the two groups. The length of the stromal scar was not significantly different between groups, though a smaller scar formation was observed in group 1 compared to those in group 2 at both 1 week and 1 month postoperatively. There was also no significant difference between the groups in tear film parameters. The stromal scar length was correlated with the Schirmer test on the 15th day. Although it was not statistically significant, the hyaluronic acid/trehalose may affect epithelial healing and stromal scar formation in a positive way after phacoemulsification surgery. Larger and longer studies are needed.
Keywords : Hyalunoric acid trehalose, Phacoemulsification surgery, Dry eye, Wound healing, Clear corneal incision