Vaccination Against SARS-CoV-2 and Mortality in Hemodialysis Patients: Three is Good

Authors : Demet YAVUZ, Düriye Sıla KARAGÖZ ÖZEN, Eşe BAŞBULUT, Melek BİLGİN, Mehmet Derya DEMİRAG

Pages : 398-403

Doi:10.19127/bshealthscience.1274888

View : 59 | Download : 70

Publication Date : 2023-07-01

Article Type : Research Paper

Abstract :This study has investigated the vaccination rates against SARS-CoV-2 infection, antibody response to vaccine types, and factors affecting mortality in maintenance hemodialysis patients.98 of 143 patients undergoing hemodialysis in our clinic had 3 doses of BNT162b2 insert ignore into journalissuearticles values(Pfizer-BioNTechh); or CoronaVac insert ignore into journalissuearticles values(Sinovac Life Sciences); vaccine. Of these 98 patients, blood samples were obtained from 52 patients who agreed to obtain serum samples before and after vaccination. The serum samples were analyzed using the Abbott SARS-CoV-2 immunoassay designed to detect IgG antibodies against the receptor-binding domain of the S1 subunit of the spike protein of SARS-CoV-2. The rate of vaccination with at least one dose of vaccine was 85.3%, and the frequency of SARS-CoV-2 infection was 58.7%. The patients whose antibody titer was obtained after the third dose of vaccine insert ignore into journalissuearticles values(n=52); were divided into two groups according to the last vaccine type, as BioNTechh group of 16 patients and the Sinovac group of 36 patients. Considering all 52 patients with 3 doses of vaccine, the median antibody level was 397.3 insert ignore into journalissuearticles values(min-max); insert ignore into journalissuearticles values(4.5-40000); before the third vaccine dose, while 1325.3 insert ignore into journalissuearticles values(min-max); insert ignore into journalissuearticles values(10.5-40000); after the third vaccine dose insert ignore into journalissuearticles values(P<0.001);. In patients with the last vaccine dose of Sinovac insert ignore into journalissuearticles values(n=36);, the median antibody titer was 168.2 insert ignore into journalissuearticles values(min-max); insert ignore into journalissuearticles values(4.5-40000); before the third vaccine dose, while 851.7 insert ignore into journalissuearticles values(min-max); insert ignore into journalissuearticles values(55.2-40.000); after the third vaccine dose insert ignore into journalissuearticles values(P<0.01);. In patients with the last vaccine dose of BioNTechh, the median antibody titer was 2738.6 insert ignore into journalissuearticles values(min-max); insert ignore into journalissuearticles values(9.4-37723.4); before the third vaccine dose, while 37575.8 insert ignore into journalissuearticles values(min-max); insert ignore into journalissuearticles values(10.5-40000); after the third vaccine dose insert ignore into journalissuearticles values(P=0.002);. The frequency of SARS-CoV-2 infection insert ignore into journalissuearticles values(P=0.001); and SARS-CoV-2 infection-related mortality rates were significantly lower in vaccinated patients than in unvaccinated patients insert ignore into journalissuearticles values(P<0.001);. SARS-CoV-2 vaccine doses elicited a high seropositive response in patients receiving maintenance dialysis. Those who received the last insert ignore into journalissuearticles values(3rd); dose of vaccine with BNT162b2 had higher antibody levels than those with CoronaVac/Sinovac. In addition, regardless of the vaccine type, being vaccinated with any of them decreased the incidence of SARS-CoV-2 infection and the mortality rate.
Keywords : COVID 19 vaccination, SARS CoV 2, Maintenance hemodialysis, Mortality