Relationship between Oxidized Low-Density Lipoprotein Treatment and Hepatocellular Carcinoma Associated Transcript 1 Expression

Authors : Burcu Bayyurt

Pages : 17-20

Doi:10.19127/bshealthscience.1588660

View : 36 | Download : 50

Publication Date : 2025-01-15

Article Type : Research Paper

Abstract :Long non-coding RNAs (lncRNAs) have multiple biological functions in the vascular system including in endothelial cells (ECs). Hepatocellular carcinoma associated transcript 1 (HULC) is a lncRNA and highly up-regulated in liver cancer. Oxidized low-density lipoprotein (ox-LDL) is a remarkable risk factor for various disease. We investigated and compared HULC expression in human umbilical vein endothelial cells (HUVECs) treated with two different concentration of ox-LDL. We used quantitative polymerase chain reaction (qPCR) method to detect HULC expression level in HUVECs. HULC expression was found to be statistic significantly up-regulated in HUVECs treated with higher concentration of ox-LDL (P<0.001). It may be put forward that high concentration of ox-LDL treatment may be inducer of HULC gene expression in variety of diseases including in cancer and cardiovascular diseases (CVDs).
Keywords : Hepatocellular carcinoma associated transcript 1, Oxidized low-density lipoprotein, Gene expression, Quantitative polymerase chain reaction