Levels of oxidative stress and apoptosis-related biomarkers in endometriosis

Authors : Dilara ÜLGER ÖZBEK, Savaş KARAKUŞ, Sevtap BAKIR

Pages : 480-488

Doi:10.17826/cumj.1247227

View : 70 | Download : 205

Publication Date : 2023-07-02

Article Type : Research Paper

Abstract :Purpose: In this study, the apoptosis marker M30, the oxidative stress markers malondialdehyde, insert ignore into journalissuearticles values(MDA); and asymmetric dimethyl arginine insert ignore into journalissuearticles values(ADMA); have been studied in the context of endometriosis. Materials and Methods: This prospective case-control study comprises 31 patients diagnosed with endometriosis and 31 controls. ADMA and M30 levels in blood serum were measured by the enzyme-linked immunosorbent assay insert ignore into journalissuearticles values(ELISA); method, and MDA levels were measured by the spectrophotometric method. In addition, some biochemical parameters and cancer antigen-125 insert ignore into journalissuearticles values(CA-125); levels were also measured. Results: M30 levels were statistically lower in endometriosis patients insert ignore into journalissuearticles values(271.5 IU/L); than in controls insert ignore into journalissuearticles values(371.3 IU/L);. ADMA levels were higher in endometriosis patients insert ignore into journalissuearticles values(19.3 ng/L); compared to controls insert ignore into journalissuearticles values(12.7 ng/L);. CA-125 levels were statistically higher in the endometriosis patients insert ignore into journalissuearticles values(65.1 U/mL); compared to the controls insert ignore into journalissuearticles values(19.0 U/mL);. There was no significant difference between the two groups in MDA levels. The results regarding dyspareunia, pelvic pain, AST, and ALP were statistically significant. Conclusion: In our study, decreased M30 levels in the patient group were associated with reduced apoptosis in endometriosis. ADMA levels, elevated with the increase of oxidative stress, were higher in the patients. MDA levels, an indicator of increased oxidative stress, were also higher in the patient group. This study constitutes the first data regarding endometriosis patients\` ADMA, M30, and MDA levels.
Keywords : Apoptoz, ADMA, endometriozis, MDA, M30