Rosuvastatin relaxes rat thoracic aorta, pulmonary artery, and trachea via nitric oxide, prostanoids, and potassium channels

Authors : Serdar ŞAHİNTÜRK

Pages : 419-431

Doi:10.17826/cumj.1279122

View : 92 | Download : 245

Publication Date : 2023-07-02

Article Type : Research Paper

Abstract :Purpose: This study aimed to determine the functional effects and mechanisms of the action of rosuvastatin on vascular and tracheal smooth muscle tissues. Materials and Methods: Vascular and tracheal rings insert ignore into journalissuearticles values(2-3 mm); isolated from the thoracic aortas, pulmonary arteries, and tracheas of Wistar Albino male rats insert ignore into journalissuearticles values(250-300 g); were placed in chambers in the isolated tissue bath system. As the resting tension, 1 g was selected. Vascular rings contracted with 10-6 M phenylephrine after a 90-minute equilibration period. Tracheal rings contracted with 10-5 M acetylcholine. After the contraction was steady, rosuvastatin insert ignore into journalissuearticles values(10-8-10-4 M); was cumulatively applied to the vascular and tracheal rings. The defined experimental methodology was repeated following the incubation of selective inhibitors of signaling pathways and K+ channel blockers to ascertain rosuvastatin\`s functional effect mechanisms. Results: In the precontracted rat vascular and tracheal rings, rosuvastatin induced concentration-dependent relaxation. The maximal relaxation level in vessel samples was 96%. On the other hand, the maximal relaxation level in tracheal samples was found to be 75%. The vasorelaxant effects of rosuvastatin were dramatically attenuated by endothelium removal, L-NAME treatment, and indomethacin incubation insert ignore into journalissuearticles values(up to 27%);. With the incubation of tetraethylammonium, glyburide, 4-Aminopyridine, and anandamide, rosuvastatin-mediated vascular smooth muscle relaxation levels were significantly decreased insert ignore into journalissuearticles values(up to 38%);. Moreover, With the incubation of tetraethylammonium, glyburide, and 4-Aminopyridine rosuvastatin-mediated tracheal smooth muscle relaxation levels were significantly decreased insert ignore into journalissuearticles values(up to 30%);. Conclusion: Rosuvastatin has a noticeable relaxing effect on the vascular and tracheal smooth muscles. The vasorelaxant effect of rosuvastatin involves intact endothelium, nitric oxide, prostanoids, and K+ channels insert ignore into journalissuearticles values(BKCa, KV, and KATP channels);. Furthermore, nitric oxide, prostanoids, BKCa channels, KV channels, and KATP channels play a role in rosuvastatin-induced tracheal smooth muscle relaxation
Keywords : Aort, nitrik oksit, potasyum, pulmoner arter, rosuvastatin, trake