Comparison of Cardiac Risk Factors in Patients with Nephrotic Syndrome and Secondary Amyloidosis

Authors : Osman CÜRE, Teslime AYAZ, Kuddusi CENGİZ

Pages : 92-97

Doi:10.56016/dahudermj.1108002

View : 18 | Download : 8

Publication Date : 2022-07-29

Article Type : Research Paper

Abstract :Proteinuria is an independent risk factor for cardiovascular diseases and for the increment of atherosclerotic mortality. Atherosclerotic risk factors are well known in the various types of nephrotic syndrome but there are only few studies comparing the same risk factors between the secondary amyloidosis and nephrotic syndrome patients those have exactly same 24- hour protein levels in the urine. According to theliterature, recent comparative studies have not shown the etiological differences of atherosclerotic risk factors in these two disease groups. The aim of this study was to investigate the risk factors caused byproteinuria on development of atherosclerosis and to determine the differences in these disease groups those were well- matched in age, gender, arterial blood pressure levels, glomerular filtration rate insert ignore into journalissuearticles values(GFR); and body mass index. These patients groups were chosen to have exactly the same 24- hour protein levels in urine. 29 patients with nephrotic syndrome, 30 patients with secondary amyloidosis and 30 people of control group were taken to the trial. C- reactive protein insert ignore into journalissuearticles values(CRP);, fibrinogen, cholesterol, triglyceride, low density lipoprotein insert ignore into journalissuearticles values(LDL-C);, high density lipoprotein insert ignore into journalissuearticles values(HDL-C);, lipoprotein -a [Lpinsert ignore into journalissuearticles values(a);], apo- lipoprotein Al insert ignore into journalissuearticles values(apo Al);, apolipoprotein B insert ignore into journalissuearticles values(apo B);, apo- lipoprotein E insert ignore into journalissuearticles values(apo E);, GFR and 24- hour protein in urine were compared between the patients and control groups. In the patients groups; cholesterol, triglyceride, LDL-C, Lpinsert ignore into journalissuearticles values(a);, apo A, apo B, apo E and fibrinogen levels were found much higher than the control group whereas HDL-C levels were lower insert ignore into journalissuearticles values(p<0.0l);. When both disease groups are compared; total cholesterol, triglyceride, LDL-C, HDL-C, apo Al, apo B and apo E levels were higher in the nephrotic syndrome group compared to the secondary amyloidosis group insert ignore into journalissuearticles values(p<0,05);, but in terms of CRP, fibrinogen, Lp insert ignore into journalissuearticles values(a); levels. There was no difference between the patient groups . As a result; Atherosclerotic risk factors are quite high in nephrotic syndrome and secondary amyloid patient groups with proteinuria, and patients with amyloidosis should be closely monitored for other atherosclerotic risk factors in addition to amyloid accumulating in the organs.
Keywords : Nephrotic Syndrome, Secondary Amyloidosis, Cardiovascular Risk factors