Approach To Diagnosis And Treatment Of Familial Hyperlipidemia

Authors : Kübra ÇERÇİ, İmge Bortay TEKİN, Seyit UYAR

Pages : 4-8

Doi:10.56016/dahudermj.1195167

View : 17 | Download : 7

Publication Date : 2023-01-29

Article Type : Review Paper

Abstract :Familial hyperlipidemia insert ignore into journalissuearticles values(FH); is an autosomal dominant inherited disease characterized by genetic disorders with severe high blood cholesterol levels. There are two forms of the disease which are homozygous and heterozygous FH. FH cases are generally caused by hereditorial mutations in the LDL receptor insert ignore into journalissuearticles values(LDL-R); gene and less commonly in genes encoding apolipoprotein B insert ignore into journalissuearticles values(Apo B); and pro-protein convertase subtilisin/kexin 9 insert ignore into journalissuearticles values(PCSK9); proteins. The risk of early-onset coronary artery disease insert ignore into journalissuearticles values(CAD); in FH patients is 20 times higher than the normal population. Early diagnosis and treatment of FH will greatly reduce the morbidity and mortality associated with CAD.
Keywords : Familial hyperlipidemia, heterozygous familial hyperlipidemia, homozygous familial hyperlipidemia, low density lipoprotein receptor mutation