THE ROLE OF CANNABIONIDES IN PERIODONTOLOGY
Authors : Merter Güçlü, Murtaza Yelbay, Şehrazat Ziya Muluk, Nilsun Bağış
Pages : 145-164
View : 86 | Download : 165
Publication Date : 2025-10-28
Article Type : Review Paper
Abstract :Hemp is a dioecious, flowering, and herbaceous plant species that has been utilized throughout human history for various properties and has a wide range of applications including the textile industry, automotive sector, aerospace, pharmaceuticals, and food supplements. The medical use of hemp dates back to the pre-Christian era and continued until the 1940s. However, due to the abuse of its psychoactive components, it has been banned in many countries. With the development of nuclear magnetic resonance spectroscopy, the chemical structure and composition of tetrahydrocannabinol, the primary component responsible for the euphoric effect of hemp, were identified. Subsequently, cannabinoid receptors, endocannabinoids, and enzymes involved in the endocannabinoid system were discovered. The term cannabinoid encompasses phytocannabinoids derived from hemp, endocannabinoids produced in the human body, and synthetic cannabinoids, all of which can bind to cannabinoid receptors in the human body. The endocannabinoid system is defined as a complex cellular signaling system comprising transmembrane cannabinoid receptors, endogenous ligands, specific uptake mechanisms, biosynthesis, and enzymatic degradation systems. The study of the interaction between the endocannabinoid system and cannabinoids has inspired new perspectives for the treatment and prevention of periodontal diseases. As a result, current research demonstrates that the endocannabinoid system and various types of cannabinoids play a significant role in the pathogenesis and treatment of conditions affecting oral tissues and cells. It has been shown that the endocannabinoid system may regulate inflammatory responses and halt the inflammation progression. Existing data support the therapeutic use of cannabinoids as a potential option for patients with periodontitis.Keywords : Kenevir, Periodontitis, HU-308, Kannabidiol, Endokannabionid Sistem
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