Is Progesterone Supplementation Necessary for Luteal Phase Support in Modified Natural Cycle Frozen Embryo Transfers?

Authors : Sevinç Özmen, Gönül Özer

Pages : 45-49

View : 27 | Download : 56

Publication Date : 2025-03-15

Article Type : Research Paper

Abstract :Introduction: This study aimed to evaluate the effect of progesterone supplementation as luteal phase support on pregnancy outcomes in women under thirty-eight years of age undergoing modified natural cycle frozen embryo transfer. Methods: A retrospective analysis was conducted on 2216 modified natural cycle frozen embryo transfers performed at Sisli Memorial Hospital, Assisted Reproductive Technology (ART), and Reproductive Genetics Centre between 2011 and 2023. The study included women under thirty-eight who transferred a single embryo, classified as top quality or good quality. Cycles involving medium-quality or poor-quality embryos, double embryo transfers, and preimplantation genetic testing for aneuploidy were excluded. Participants were categorised into three groups: Group A (n=493) with no luteal phase support, Group B (n=1327) receiving 200 mg of vaginal micronised progesterone twice daily, and Group C (n=396) receiving 200 mg of vaginal micronised progesterone plus 25 mg of subcutaneous progestin daily. Statistical analysis was performed using SPSS 22. Results: Demographic and fresh cycle characteristics were similar among groups. There were no statistically significant differences in pregnancy outcomes: live birth rates were 58.4% (A), 60.8% (B), and 60.1% (C) (p=0.650); clinical pregnancy rates were 65.9% (A), 69.1% (B), and 68.2% (C) (p=0.432); biochemical abortion rates were 4.5% (A), 6.6% (B), and 5.3% (C) (p=0.186); and clinical abortion rates were 6.3% (A), 6.7% (B), and 5.3% (C) (p=0.828). Conclusions: Modified natural cycle frozen embryo transfers in women under 38 years of age showed similar pregnancy outcomes regardless of using progesterone for luteal phase support.
Keywords : Modifiye doğal siklusta dondurulmuş embriyo transferi, luteal faz desteği, progesteron takviyesi.