A Look To The Relationship Between Autophagy And Embryonal Carcinoma From A Different Perspective

Authors : Şeyma Kipel, Hilal Nakkaş

Pages : 61-66

View : 41 | Download : 78

Publication Date : 2025-03-15

Article Type : Research Paper

Abstract :Introduction: Testicular embryonal carcinoma is a type of testicular cancer that affects the germ cells which are the precursors of sperm cells that will eventually develop into sperm. These carcinoma cells are often aggressive. In such cells, autophagy may promote the survival and proliferation of cancer cells, as autophagy can help cells survive under stress. Autophagy may also allow cancer cells to develop resistance to their environment and to metastasize. ATG4 (Autophagy related 4) is a protein that plays a role in the initiation of autophagy. JAB1 (Jun activation domain binding protein 1) is a protein involved in cellular signaling and regulates many biological processes such as cell cycle, apoptosis, and gene expression. JAB1 is also involved in the regulation of the p27 protein, and its high expression can be observed in cancer cells. NEDL2 (Neuroepithelial differentiation marker like 2) is involved in cellular growth and developmental processes. It is also a protein that is thought to play a role in cancer progression. The aim of the study was to demonstrate expression and localization of ATG4, JAB1 and NEDL2 in testicular embryonal carcinoma cells. Methods: The morphological examination of testis embryonal carcinoma cells were performed by using hematoxylin eosin (H-E) staining. Then, using the immunohistochemical technique, cellular expression and location of ATG4, JAB1 and NEDL2 in testis embryonal carcinoma cells were examined. Results: According to immunohistochemistry results, ATG4, JAB1 and NEDL2 expression was detected in human testicular embryonal carcinoma cells. Conclusions: By determining the expression levels of these three proteins, more information can be obtained about how important processes such as autophagy, cell cycle regulation and cellular development are affected in testicular embryonal carcinoma. This information could be an important step in understanding the biology of cancer and developing treatment strategies.
Keywords : Testis embriyonal karsinom, otofaji, ATG4, JAB1, NEDL2