A SIMULATION STUDY ON NEUROMUSCULAR FACTORS AFFECTING CONSECUTIVE MOTOR UNIT ACTION POTENTIAL WAVESHAPE

Authors : Kamil SAVAŞ, Yasin GÖKÇE, Armando TRIGUEROS, Nazmi YARAŞ

Pages : 582-591

Doi:10.18038/estubtda.830739

View : 14 | Download : 9

Publication Date : 2020-12-28

Article Type : Research Paper

Abstract :Quantification of consecutive motor unit potential insert ignore into journalissuearticles values(MUP); is used to diagnose and monitor the progress of neuromuscular pathologies in clinical applications. In this study, a detailed motor unit simulation was conducted to reveal and understand the factors affecting MUPs. Using a volume conductor model and real muscle parameters, normal and pathologic MUPs were created. The shape changes observed in consecutive MUPs, called jiggle, are calculated with a quantification method. Increased jitter duration and re-innervation percentage commonly observed during motor unit loss increase the jiggle value proportionally. Moreover, increasing fiber density changing different regions of a muscle bundle decreases the jiggle value. The blocking phenomena generally observed in re-innervated fibers affects the jiggle value similar to jitter duration. But, higher blocking levels insert ignore into journalissuearticles values(50%); of re-innervated motor fiber do not have an effect on jiggle value as lower levels of blocking insert ignore into journalissuearticles values(20%);. In conclusion, simulation of pathological MUPs showed that it is useful for clinicians to understand the progress of a neuromuscular pathology and the factors affecting consecutive MUP wave shape.
Keywords : Motor Unit Action Potential, Neuromuscular Pathology, Motor Unit Instability, Motor Unit Simulation